Muscarinic receptor agonists

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utoledo_1343.pdf (326.83 KB)

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United States Patent and Trademark Office

Abstract

Description

A compound of Formula (I): ##STR1## wherein R is independently selected from (CH2)9-12, (CH2 CH2)2 O, (CH2 CH2)3 O2, (CH2 CH2)4 O3, (CH2 CH2)5 O4, (CH2 CH2)6 O5 or (CH2 CH2 CH2)3 O2 ; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.

Keywords

514/342, 546/187, 546/268.7

Citation

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https://hdl.handle.net/20.500.14324/6326

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University of Toledo U.S. Patents