Development of a cofilin inhibitor for the treatment of hemorrhagic brain injury-induced neuroinflammation

Files

utoledo_14224.pdf (765.95 KB)

Date

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

United States Patent and Trademark Office

Abstract

Description

Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-α, reducing NF-κB, and improving motor deficits in a subject are described.

Keywords

C07F7/18, C07C275/26, A61P25/28

Citation

URI

https://hdl.handle.net/20.500.14324/6907

DOI

Collections

University of Toledo U.S. Patents