Conformationally restrained epothilone analogues as anti-leukemic agents
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United States Patent and Trademark Office
Abstract
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A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain.
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Keywords
514/228.2, 514/323, 540/602, 544/373, 546/147, 546/200, 548/517