Contrast agents for image enhancement in magnetic resonance imaging

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United States Patent and Trademark Office

Abstract

Description

A compound of formula (I): ##STR1## wherein, R1, R2, R3 and R4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R1, R2 and R3, R4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.

Keywords

424/9.36, 424/9.361, 514/182, 514/502, 514/836, 544/64, 544/78, 548/402, 548/523, 556/138, 556/139, 564/82

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https://hdl.handle.net/20.500.14324/6294

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University of Toledo U.S. Patents