Inhibitors of ERCC1-XPF and methods of using the same
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United States Patent and Trademark Office
Abstract
Description
Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
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Keywords
A61K33/24, A61K31/185, A61K31/255, A61K45/06, C07C309/47, C07C309/67, C07C309/73, C07C317/36, C07C323/66