The Role of Nicotinic Acid Adenine Dinucleotide Phosphate in B Cells Calcium Flux
| dc.contributor | Pianhong, Han (author) | |
| dc.contributor | Dr. Katherine Wal (advisor) | |
| dc.date | 2018-08-31 | |
| dc.date.accessioned | 2024-05-26T12:30:47Z | |
| dc.date.available | 2024-05-26T12:30:47Z | |
| dc.description | Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most recently discovered Ca2+ signaling second messenger. The investigation of NAADP in T lymphocytes, conducted by Dr. Katherine A. Wall’s lab, has demonstrated the importance of NAADP as a Ca2+ mobilizing second messenger in naive and effector murine T cells. The success indicates that NAADP contributes prominently to Ca2+ during activation of the cells. However, no one has particularly investigated the role that NAADP plays in B lymphocytes. The project I am working on is to explore the function of NAADP in B cells by calcium flux. I am using Ned-19, an inhibitor of the NAADP signaling pathway, to indicate the presence of NAADP signaling.Investigating whether NAADP has an essential effect in B cell function as it does in naive and effector murine T cells will bring more understanding to the cell and cell functioning as a whole. The research will also enhance our current knowledge about NAADP, and one of the benefits is to help us better target the Ca2+ release mechanism with specific drugs. Therefore, enlightening us in causes of many autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, which may lead to new treatments for those diseases and contribute to the advancement of immunology and pharmacology. | |
| dc.format | 1 p.,application/pdf | |
| dc.identifier | utoledo:449 | |
| dc.identifier | iid: 2018-EOS-Han-The-Role-Of-Nicotininc-Acid | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14324/7838 | |
| dc.language.iso | eng | |
| dc.relation | Scholars' Celebration & End-of-Summer Symposium Posters & Presentations, 2017-18 | |
| dc.rights | In Copyright | |
| dc.rights.uri | https://rightsstatements.org/vocab/InC/1.0/ - In Copyright | |
| dc.title | The Role of Nicotinic Acid Adenine Dinucleotide Phosphate in B Cells Calcium Flux | |
| dc.type | poster | |
| dc.type | Text |
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