Methods of treatment of cancer using SRC-modulating peptides
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United States Patent and Trademark Office
Abstract
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A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. Also disclosed is use of said Src-modulating peptides for treatment of cancer.
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A61K38/10, C07K14/47, A61K38/45, A61K38/46, C07K7/08, G01N33/573, A61K38/17