Modified plasminogen activator inhibitor type-1 and methods based thereon

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dc.contributorMedical College of Ohio
dc.contributorSwiercz, Rafal
dc.contributorSelman, Steven H.
dc.contributorJankun, Jerzy
dc.contributorChorostowska-Wynimko, Joanna
dc.contributorSkrzypczak-Jankun, Ewa
dc.date2009-09-22
dc.date.accessioned2024-05-26T01:52:59Z
dc.date.available2024-05-26T01:52:59Z
dc.descriptionThe present invention is based upon the discovery that modified plasminogen activator inhibitor type-I (PAI-1) in which two or more amino acid residues that do not contain a sulfhydryl group have been replaced with amino acid residues that contain a sulfhydryl group and, therefore, forms intramolecular disulfide bonds, have increased in vivo half-life. Also disclosed are the modified PAI-1 proteins, derivatives and analogs thereof, specific antibodies, nucleic acid molecules and host cells. Methods for producing modified PAI-1, derivatives and analogs are also provided. The invention further relates to Therapeutics, pharmaceutical compositions and method of using the composition for treatment. The invention may be used to inhibit angiogenesis in a subject, thereby treating diseases or conditions associated with undesired angiogenesis and cell proliferation. Such conditions include psoriasis, chronic inflammation, tumor invasion and metastasis and conditions in which angiogenesis is pathogenic. The modifide PAI-1 molecules of the present invention are useful for the treatment, prophylaxis, management and amelioration of cardiovascular diseases such as, but not limited to those that are related to hyperfibrinolysis, hemophilia, and vessel leakage syndrome.
dc.formatapplication/pdf
dc.identifierutoledo:1384
dc.identifieriid:utpatents-US7592422
dc.identifierPatent No.: US7592422
dc.identifierAppl. No.: 10/506406
dc.identifier.urihttps://hdl.handle.net/20.500.14324/6700
dc.language.isoeng
dc.publisherUnited States Patent and Trademark Office
dc.rightsNo Copyright - United States
dc.subject530/350
dc.subject530/300
dc.titleModified plasminogen activator inhibitor type-1 and methods based thereon
dc.typeText
dc.typepatent

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