Method of treating blood which comprises use of diels alder adducts of vinyl porphyrins and metal complexes thereof

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dc.contributorThe University of Toledo; Medical College of Ohio
dc.contributorMorgan, Alan R.
dc.contributorSelman, Steven H.
dc.date2000-02-15
dc.date.accessioned2024-05-25T13:18:58Z
dc.date.available2024-05-25T13:18:58Z
dc.descriptionFamilies of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the structures of Formulas 3 and 4, below: ##STR1## where R1, R2, R3 and R4 can be the same or different, and each is methyl, ethyl, an amino acid moiety which is a part of an amide produced by reaction between an amine function of a naturally occurring amino acid and a carbonyl function of the adduct, or a monoclonal antibody moiety which is attached to the adduct moiety through a carbonyl which is a part of an amide produced by reaction between an amine function of a monoclonal antibody and a CO2 R', CH2 CO2 R' or CH2 CH2 CO2 R'group of the adduct, and wherein the moiety is of a monoclonal antibody which selectively binds to malignant tumors, R5, R6 and R7 can be the same or different, and each is ethyl, an amino acid moiety which is a part of an amide produced by reaction between an amine function of a naturally occurring amino acid and a carbonyl function of the adduct, or a monoclonal antibody moiety which is attached to the adduct moiety through a carbonyl which is a part of an amide produced by reaction between an amine function of a monoclonal antibody and a CO2 R', CH2 CO2 R' or CH2 CH2 CO2 R'group of the adduct, and wherein the moiety is of a monoclonal antibody which selectively binds to malignant tumors, M comprises 2H or a metal cation, e.g., Sn or Zn, that is complexed with two of the nitrogens of the adduct, and R8 is an alkyl group other than t-butyl having from one to four carbon atoms. The use of the adducts and complexes in PHD is also disclosed.
dc.formatapplication/pdf
dc.identifierutoledo:1335
dc.identifieriid:utpatents-US6025351
dc.identifierPatent No.: US6025351
dc.identifierAppl. No.: 08/979643
dc.identifier.urihttps://hdl.handle.net/20.500.14324/6241
dc.language.isoeng
dc.publisherUnited States Patent and Trademark Office
dc.rightsNo Copyright - United States
dc.subject514/185
dc.subject534/13
dc.subject534/14
dc.subject534/15
dc.subject534/16
dc.subject540/145
dc.subject604/5.01
dc.titleMethod of treating blood which comprises use of diels alder adducts of vinyl porphyrins and metal complexes thereof
dc.typeText
dc.typepatent

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