Stable Tregs and related materials and methods

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dc.contributorThe University of Toledo
dc.contributorStepkowski, Stanislaw M.
dc.contributorChen, Wenhao
dc.contributorMiyahara, Yoshihiro
dc.date2015-04-28
dc.date.accessioned2024-05-26T01:55:23Z
dc.date.available2024-05-26T01:55:23Z
dc.descriptionThe present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants.
dc.formatapplication/pdf
dc.identifierutoledo:1452
dc.identifieriid:utpatents-US9018006
dc.identifierPatent No.: US9018006
dc.identifierAppl. No.: 13/811778
dc.identifier.urihttps://hdl.handle.net/20.500.14324/6940
dc.language.isoeng
dc.publisherUnited States Patent and Trademark Office
dc.rightsNo Copyright - United States
dc.subject435/377
dc.subject435/325
dc.titleStable Tregs and related materials and methods
dc.typeText
dc.typepatent

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