Cancer diagnosis and therapy based on mutations in TGF-receptors
Date
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
Description
This invention is based on the discovery that the type II TGF~receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use incancer diagnosis or prognosis.
item.page.type
Text
patent
patent
item.page.format
application/pdf
Keywords
435/69.1, 435/325, 530/350