IL-12 inhibition of B1 cell activity
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United States Patent and Trademark Office
Abstract
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The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the invention relates to a method of treating a B1 cell disorder in a host, comprising administering to the host an effective therapeutic amount of IL-12. The invention further encompasses a method of screening for substances (e.g., proteins, peptides, small molecules) which enhance or suppress the inhibition of B1 cell activity by IL-12. The invention also relates to a substance identified by the methods of screening for a substance which enhances or suppresses IL-12 inhibition of B1 cell activity.
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Keywords
424/85.2, 514/3.8, 514/4.3, 514/7.3, 514/16.6, 514/17.5, 514/17.9, 514/19.6