Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
| dc.contributor | The University of Toledo | |
| dc.contributor | Erhardt, Paul W. | |
| dc.contributor | Aouthmany, Moustafa M. | |
| dc.date | 2004-06-29 | |
| dc.date.accessioned | 2024-05-25T19:13:39Z | |
| dc.date.available | 2024-05-25T19:13:39Z | |
| dc.description | A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious parent drug compound so as to retain efficacy while re-directing a preferred route and rate of the parent drug compound's metabolism to an inactive or very weakly active and non-toxic metabolite are disclosed. The chemical arrangement is wherein f is a phenyl, substituted aryl or heteroaryl system that is already present in the parent drug compound or is specifically added to the parent drug compound via a metabolically stable connection;R is an alkyl or alkene containing chain either branched or unbranched from 0 to 10 carbons that is already present in the parent drug compound or is added to the parent drug compound via a metabolically stable connection to f;X is a carboxyl, sulfoxyl or phosphatyl function that is specifically added to the parent drug compound via a metabolically stable connection to R; and,R' is an added alkyl, alkenyl or aralkyl group either branched or unbranched containing from 1 to 10 carbons, or is a structural element already present as an inherent portion of the parent drug compound. | |
| dc.format | application/pdf | |
| dc.identifier | utoledo:1363 | |
| dc.identifier | iid:utpatents-US6756047 | |
| dc.identifier | Patent No.: US6756047 | |
| dc.identifier | Appl. No.: 10/299044 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14324/6472 | |
| dc.language.iso | eng | |
| dc.publisher | United States Patent and Trademark Office | |
| dc.rights | No Copyright - United States | |
| dc.subject | 424/422 | |
| dc.title | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs | |
| dc.type | Text | |
| dc.type | patent |
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