Method for modulating pigmentation by targeting BET bromodomain proteins

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utoledo_1212.pdf (1.01 MB)

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United States Patent and Trademark Office

Abstract

Description

Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein inhibitors, such as JQ1, are used to reduce pigmentation, promote cell cycle arrest, inhibit the expression of TYR, TRP1, and DCT proteins, inhibit the expression of TYR mRNA, and suppress melanocyte proliferation.

Keywords

A61K8/49, A61Q19/02

Citation

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https://hdl.handle.net/20.500.14324/5136

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University of Toledo U.S. Patents