Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor

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utoledo_1360.pdf (1.17 MB)

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United States Patent and Trademark Office

Abstract

Description

Novel sulfate ester agents and the use of those agents for treating gastroesophageal reflux disease (GERD) are described, exemplary agents being of the formula [not included]: wherein Xis -OCH 2- or -CH 2 O-; Y is a group pendant from X comprising at least one -OSO 3 R 4 moiety, wherein R4 is H or a pharmaceutically acceptable cation; n is an integer from 1-3; and R 1 and R 2 are each independently selected from the group consisting of -H, a halogen with an atomic number from 9 to 53, -SO3 R4, -NCS, -NCO, -NH(CO)-OR 3 , -NH(CS)SR 3 , -NH(C=NH)OR 3 , -NHCOCH 2 Cl, -NHCOCH 2 Br, -NHCO-CH=CH 2 , -NHC(O)-CF 3 , wherein R 4 is H or a pharmaceutically acceptable cation.

Keywords

514/516, 558/11; 558/13, 558/14, 514/520

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https://hdl.handle.net/20.500.14324/6463

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University of Toledo U.S. Patents