IL-12 Stimulation of Neonatal immunity
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United States Patent and Trademark Office
Abstract
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The present invention relates to a method of inducing a Th1-like response against a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of overcoming suppression of interferon-? (IFN-?) expression in a neonatal host due to exposure of the neonatal host to a pathogen or an antigen, which comprises administering to the neonatal host an effective amount of IL-12 and the antigen. The present invention also relates to a method of enhancing the cytokine expression against or in response to a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen.
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Keywords
424/85.2, 424/85.4, 424/184.1, 424/191.1, 424/204.1, 424/234.1, 424/264.1, 424/269.1, 530/350