Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
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Abstract/Description: | Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed. |
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Subject(s): | C07D277/22 C07D277/24 |
Date Issued: | 2019-08-27 |
Title: | Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer. |
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Name(s): |
Tillekeratne, Viranga, inventor Taylor, William, inventor Fedorka, Sara, inventor The University of Toledo, assignee |
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Type of Resource: | text | |
Genre: | patent | |
Date Issued: | 2019-08-27 | |
Other Date: | Date Filed: 2018-09-25 | |
Publisher: | United States Patent and Trademark Office | |
Physical Form: | application/pdf | |
Extent: | 18 p. | |
Abstract/Description: | Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed. | |
Identifier(s): |
utpatents-US10392354 (IID) Patent No.: US10392354 (patno) Appl. No.: 16/141595 (appno) |
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Subject(s): |
C07D277/22 C07D277/24 |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
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