Discovering Potential Novel Anthelmintics using C. elegans

This investigation focuses on determining how PAPP’s components work in hopes of finding new ways to combat parasitic nematodes. Worms lacking certain neural receptors involved in pharyngeal pumping were exposed to each of the different components. By studying the effect of the compounds on the rate of pharyngeal pumping in each of the different strains, the pathways of the different drugs could be highlighted and receptor complexes involved could be isolated for further study.  At the moment, few anthelmintic drugs dominate the farming industry leading to increasing resistance and devastation. By looking into the effects of different compounds, we are paving a path for new drugs to fight parasitic worms and decrease the chance for resistance, thus creating healthier crops, livestock, and even people.
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Abstract/Description: This investigation focuses on determining how PAPP’s components work in hopes of finding new ways to combat parasitic nematodes. Worms lacking certain neural receptors involved in pharyngeal pumping were exposed to each of the different components. By studying the effect of the compounds on the rate of pharyngeal pumping in each of the different strains, the pathways of the different drugs could be highlighted and receptor complexes involved could be isolated for further study. At the moment, few anthelmintic drugs dominate the farming industry leading to increasing resistance and devastation. By looking into the effects of different compounds, we are paving a path for new drugs to fight parasitic worms and decrease the chance for resistance, thus creating healthier crops, livestock, and even people.
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