The Role of Nicotinic Acid Adenine Dinucleotide Phosphate in B Cells Calcium Flux
Download pdf
Abstract/Description: | Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most recently discovered Ca2+ signaling second messenger. The investigation of NAADP in T lymphocytes, conducted by Dr. Katherine A. Wall’s lab, has demonstrated the importance of NAADP as a Ca2+ mobilizing second messenger in naive and effector murine T cells. The success indicates that NAADP contributes prominently to Ca2+ during activation of the cells. However, no one has particularly investigated the role that NAADP plays in B lymphocytes. The project I am working on is to explore the function of NAADP in B cells by calcium flux. I am using Ned-19, an inhibitor of the NAADP signaling pathway, to indicate the presence of NAADP signaling.Investigating whether NAADP has an essential effect in B cell function as it does in naive and effector murine T cells will bring more understanding to the cell and cell functioning as a whole. The research will also enhance our current knowledge about NAADP, and one of the benefits is to help us better target the Ca2+ release mechanism with specific drugs. Therefore, enlightening us in causes of many autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, which may lead to new treatments for those diseases and contribute to the advancement of immunology and pharmacology. |
---|---|
Subject(s): | |
Date Created: | 2018-08-31 |
Title: | The Role of Nicotinic Acid Adenine Dinucleotide Phosphate in B Cells Calcium Flux. |
|
---|---|---|
Name(s): |
Pianhong, Han, author Dr. Katherine Wal, advisor |
|
Type of Resource: | text | |
Genre: | poster | |
Date Created: | 2018-08-31 | |
Physical Form: | application/pdf | |
Extent: | 1 p. | |
Abstract/Description: | Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most recently discovered Ca2+ signaling second messenger. The investigation of NAADP in T lymphocytes, conducted by Dr. Katherine A. Wall’s lab, has demonstrated the importance of NAADP as a Ca2+ mobilizing second messenger in naive and effector murine T cells. The success indicates that NAADP contributes prominently to Ca2+ during activation of the cells. However, no one has particularly investigated the role that NAADP plays in B lymphocytes. The project I am working on is to explore the function of NAADP in B cells by calcium flux. I am using Ned-19, an inhibitor of the NAADP signaling pathway, to indicate the presence of NAADP signaling.Investigating whether NAADP has an essential effect in B cell function as it does in naive and effector murine T cells will bring more understanding to the cell and cell functioning as a whole. The research will also enhance our current knowledge about NAADP, and one of the benefits is to help us better target the Ca2+ release mechanism with specific drugs. Therefore, enlightening us in causes of many autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, which may lead to new treatments for those diseases and contribute to the advancement of immunology and pharmacology. | |
Identifier(s): | 2018-EOS-Han-The-Role-Of-Nicotininc-Acid (IID) | |
Subject(s): |
|
|
Held by: | The University of Toledo | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | IN COPYRIGHT | |
Related Title: |
|
|
In Collections: |