Inhibitors of ERCC1-XPF and methods of using the same
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Abstract/Description: | Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described. |
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Subject(s): | A61K33/24 A61K31/185 A61K31/255 A61K45/06 C07C309/47 C07C309/67 C07C309/73 C07C317/36 C07C323/66 |
Date Issued: | 2017-11-21 |
Title: | Inhibitors of ERCC1-XPF and methods of using the same. |
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Name(s): |
The University of Toledo, assignee Patrick, Stephan M., inventor Erhardt, Paul W., inventor Trabbic, Christopher J., inventor |
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Type of Resource: | text | |
Genre: | patent | |
Publisher: | United States Patent and Trademark Office | |
Other Date: | Date Filed: 2014-11-25 | |
Date Issued: | 2017-11-21 | |
Physical Form: | application/pdf | |
Extent: | 15 p. | |
Abstract/Description: | Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described. | |
Identifier(s): |
utpatents-US9821008 (IID) Patent No.: US9821008 (patno) Appl. No.: 15/038585 (appno) |
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Subject(s): |
A61K33/24 A61K31/185 A61K31/255 A61K45/06 C07C309/47 C07C309/67 C07C309/73 C07C317/36 C07C323/66 |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
In Collections: |