Inhibitors of ERCC1-XPF and methods of using the same

Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
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Abstract/Description: Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
Subject(s): A61K33/24
A61K31/185
A61K31/255
A61K45/06
C07C309/47
C07C309/67
C07C309/73
C07C317/36
C07C323/66
Date Issued: 2017-11-21