Treatment of cancers with A-8R peptide

The present invention provides materials and methods useful to treat various sGCa1-expressing cancers. Materials include peptides which interfere with sGCa1's pro-survival functions, thereby resulting in apoptosis of sGCa1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
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Abstract/Description: The present invention provides materials and methods useful to treat various sGCa1-expressing cancers. Materials include peptides which interfere with sGCa1's pro-survival functions, thereby resulting in apoptosis of sGCa1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
Subject(s): A61K38/10
A61K31/7048
C07K7/06
C07K7/08
A61K38/08
A61K38/00
Date Issued: 2016-03-29