Stable Tregs and related materials and methods
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Abstract/Description: | The present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants. |
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Subject(s): | 435/377 435/325 |
Date Issued: | 2015-04-28 |
Title: | Stable Tregs and related materials and methods. |
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Name(s): |
The University of Toledo, assignee Stepkowski, Stanislaw M., inventor Chen, Wenhao, inventor Miyahara, Yoshihiro, inventor |
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Type of Resource: | text | |
Genre: | patent | |
Publisher: | United States Patent and Trademark Office | |
Other Date: | Date Filed: 2011-07-25 | |
Date Issued: | 2015-04-28 | |
Physical Form: | application/pdf | |
Extent: | 40 p. | |
Abstract/Description: | The present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants. | |
Identifier(s): |
utpatents-US9018006 (IID) Patent No.: US9018006 (patno) Appl. No.: 13/811778 (appno) |
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Subject(s): |
435/377 435/325 |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
In Collections: |