Materials and methods related to sodium/potassium adenosine triphosphase and cholesterol

This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.
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Abstract/Description: This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.
Subject(s): 435/375
435/7.1
435/7.4
Date Issued: 2014-09-16
Title: Materials and methods related to sodium/potassium adenosine triphosphase and cholesterol.
Name(s): The University of Toledo, assignee
Xie, Zi-jian, inventor
Chen, Yiliang, inventor
Wang, Haojie, inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 2011-01-13
Date Issued: 2014-09-16
Physical Form: application/pdf
Extent: 23 p.
Abstract/Description: This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.
Identifier(s): utpatents-US8835171 (IID)
Patent No.: US8835171 (patno)
Appl. No.: 13/521864 (appno)
Subject(s): 435/375
435/7.1
435/7.4
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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