Use of formin agonists in overcoming brain tumor radio- and chemo-resistance by targeting tumor microtubes

Compositions and methods for inhibiting brain tumor proliferation, or for inhibiting or halting TM formation, invasion, and/or proliferation, or for rendering brain tumor cells sensitive to chemotherapy or radiation, or for treating a brain tumor, or for inducing cell death, involving mDia agonists such as IMM01 and IMM02, are described.
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Abstract/Description: Compositions and methods for inhibiting brain tumor proliferation, or for inhibiting or halting TM formation, invasion, and/or proliferation, or for rendering brain tumor cells sensitive to chemotherapy or radiation, or for treating a brain tumor, or for inducing cell death, involving mDia agonists such as IMM01 and IMM02, are described.
Subject(s): A61K45/06
A61K31/175
A61P35/00
Date Issued: 2023-01-10