Development of a cofilin inhibitor for the treatment of hemorrhagic brain injury-induced neuroinflammation

Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-α, reducing NF-κB, and improving motor deficits in a subject are described.
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Abstract/Description: Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-α, reducing NF-κB, and improving motor deficits in a subject are described.
Subject(s): C07F7/18
C07C275/26
A61P25/28
Date Issued: 2023-01-10