Vacuole-inducing compounds, methods of making and using the same

Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
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Abstract/Description: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
Subject(s): C12N5/00
A61K31/4439
A61K31/53
A61K31/5377
C12N1/38
Date Issued: 2023-03-14