Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases
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Abstract/Description: | A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. |
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Subject(s): | 530/326 530/300 530/324 |
Date Issued: | 2012-10-09 |
Title: | Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases. |
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Name(s): |
The University of Toledo, assignee Xie, Zi-jian, inventor Shapiro, Joseph I., inventor Tian, Jiang, inventor |
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Type of Resource: | text | |
Genre: | patent | |
Publisher: | United States Patent and Trademark Office | |
Other Date: | Date Filed: 2007-10-31 | |
Date Issued: | 2012-10-09 | |
Physical Form: | application/pdf | |
Extent: | 70 p. | |
Abstract/Description: | A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | |
Identifier(s): |
utpatents-US8283441 (IID) Patent No.: US8283441 (patno) Appl. No.: 12/446856 (appno) |
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Subject(s): |
530/326 530/300 530/324 |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
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