Method for the selective removal of acyl-functionality attached to the 2'-hydroxy-group of paclitaxel-related derivatives
| Title: | Method for the selective removal of acyl-functionality attached to the 2'-hydroxy-group of paclitaxel-related derivatives. |
|
|---|---|---|
| Name(s): |
The University of Toledo, assignee Erhardt, Paul W., inventor Klis, Wieslaw A., inventor Sarver, Jefferey G., inventor |
|
| Type of Resource: | text | |
| Genre: | patent | |
| Publisher: | United States Patent and Trademark Office | |
| Other Date: | Date Filed: 2002-09-27 | |
| Date Issued: | 2005-01-25 | |
| Physical Form: | application/pdf | |
| Extent: | 11 p. | |
| Abstract/Description: | A method for removing acyl-groups appended by an ester linkage to the 2'-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2',7-bis-Monochloroacetylpaclitaxel analogs are converted to their corresponding 7-monochloroacetyl derivatives by treatment with alcohol under non-acidic conditions | |
| Identifier(s): |
utpatents-US6846937 (IID) Patent No.: US6846937 (patno) Appl. No.: 10/491576 (appno) |
|
| Subject(s): |
549/510 549/511 |
|
| Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
| Location: | University of Toledo Digital Repository | |
| Rights Statement: | No Copyright - United States | |
| In Collections: |