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Abstract/Description: This invention is based on the discovery that the type II TGF-beta receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
Subject(s): 435/69.1
Date Issued: 2003-10-07