Muscarinic receptor agonists

A compound of Formula (III): wherein X is a linkage independently selected from (CH2)12 or (CH2CH2)4O3 and wherein R3 is independently selected from H, CH2CH3, COCH3 or and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
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Abstract/Description: A compound of Formula (III): wherein X is a linkage independently selected from (CH2)12 or (CH2CH2)4O3 and wherein R3 is independently selected from H, CH2CH3, COCH3 or and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
Subject(s): 546/268.7
Date Issued: 2002-04-23
Title: Muscarinic receptor agonists.
Name(s): The University of Toledo, assignee
Messer, William S., inventor
Cao, Yang, inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 2001-01-29
Date Issued: 2002-04-23
Physical Form: application/pdf
Extent: 10 p.
Abstract/Description: A compound of Formula (III): wherein X is a linkage independently selected from (CH2)12 or (CH2CH2)4O3 and wherein R3 is independently selected from H, CH2CH3, COCH3 or and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
Identifier(s): utpatents-US6376675 (IID)
Patent No.: US6376675 (patno)
Appl. No.: 09/772143 (appno)
Subject(s): 546/268.7
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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