IL-12 enhancement of immune responses to T-independent antigens
| Title: | IL-12 enhancement of immune responses to T-independent antigens. |
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|---|---|---|
| Name(s): |
Medical College of Ohio, assignee Metzger, Dennis W., inventor Buchanan, Renee M., inventor |
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| Type of Resource: | text | |
| Genre: | patent | |
| Publisher: | United States Patent and Trademark Office | |
| Other Date: | Date Filed: 1998-03-05 | |
| Date Issued: | 2001-10-16 | |
| Physical Form: | application/pdf | |
| Extent: | 22 p. | |
| Abstract/Description: | The present invention relates to a method of modulating an immune response to a T-cell or thymus independent antigen in a host (e.g., mammalian, including human), comprising administering to the host an effective amount of interleukin-12 (IL-12) and the T-cell independent antigen. In one embodiment, the present invention relates to a method of inducing an immune response to a TI antigen in a host (e.g., mammalian, including human), which comprises administering to the host an effective amount of interleukin-12 (IL-12) and the TI antigen. In another embodiment, the present invention relates to a method of enhancing an immune response against a TI antigen in a host, which comprises administering to the host an effective amount of IL-12 and the TI antigen. The methods of the present invention can be used, for example, to induce and or enhance a humoral immune response (IgG2a and/or IgG3 humoral immune response). | |
| Identifier(s): |
utpatents-US6303114 (IID) Patent No.: US6303114 (patno) Appl. No.: 09/035594 (appno) |
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| Subject(s): |
424/85.2 424/184.1 424/190.1 424/198.1 514/2.6 514/2.8 514/54 514/885 |
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| Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
| Location: | University of Toledo Digital Repository | |
| Rights Statement: | No Copyright - United States | |
| In Collections: |