utpatents-US6291237
| Title: | Cancer diagnosis and therapy based on mutations in TGF-beta receptors. |
|
|---|---|---|
| Name(s): |
Case Western Reserve University; Medical College of Ohio, assignee Markowitz, Sanford D., inventor Brattain, Michael G., inventor Willson V, James K., inventor |
|
| Type of Resource: | text | |
| Genre: | patent | |
| Publisher: | United States Patent and Trademark Office | |
| Other Date: | Date Filed: 1999-01-29 | |
| Date Issued: | 2001-09-18 | |
| Physical Form: | application/pdf | |
| Extent: | 30 p. | |
| Abstract/Description: | This invention is based on the discovery that the type II TGF-beta receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis. | |
| Identifier(s): |
utpatents-US6291237 (IID) Patent No.: US6291237 (patno) Appl. No.: 09/239864 (appno) |
|
| Subject(s): |
435/325 435/252.3 435/254.11 435/320.1 435/419 536/23.5 536/24.31 |
|
| Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
| Location: | University of Toledo Digital Repository | |
| Rights Statement: | No Copyright - United States | |
| In Collections: |