Muscarinic receptor agonists

A compound of Formula (I): ##STR1##   wherein R is independently selected from (CH2)9-12, (CH2 CH2)2 O, (CH2 CH2)3 O2, (CH2 CH2)4 O3, (CH2 CH2)5 O4, (CH2 CH2)6 O5 or (CH2 CH2 CH2)3 O2 ; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
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Abstract/Description: A compound of Formula (I): ##STR1## wherein R is independently selected from (CH2)9-12, (CH2 CH2)2 O, (CH2 CH2)3 O2, (CH2 CH2)4 O3, (CH2 CH2)5 O4, (CH2 CH2)6 O5 or (CH2 CH2 CH2)3 O2 ; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
Subject(s): 514/342
546/187
546/268.7
Date Issued: 2001-04-03