Stable cell lines capable of expressing the adeno-associated virus replication gene

Stable packaging cell lines derived from human 293 cells which are transfected with an AAV vector having the AAV rep gene operably line to a heterologous transcription promoter, such as the metallothionein promoter, or an AAV Rep78 insensitive homologous promoter and which are capable of producing AAV Rep proteins and being useful for packaging recombinant AAV vectors containing target polynucleotides.
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Abstract/Description: Stable packaging cell lines derived from human 293 cells which are transfected with an AAV vector having the AAV rep gene operably line to a heterologous transcription promoter, such as the metallothionein promoter, or an AAV Rep78 insensitive homologous promoter and which are capable of producing AAV Rep proteins and being useful for packaging recombinant AAV vectors containing target polynucleotides.
Subject(s): 435/69.1
435/235.1
435/320.1
435/369
Date Issued: 1998-11-17
Title: Stable cell lines capable of expressing the adeno-associated virus replication gene.
Name(s): Medical College of Ohio, assignee
Trempe, James P., inventor
Yang, Qicheng, inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 1995-01-09
Date Issued: 1998-11-17
Physical Form: application/pdf
Extent: 17 p.
Abstract/Description: Stable packaging cell lines derived from human 293 cells which are transfected with an AAV vector having the AAV rep gene operably line to a heterologous transcription promoter, such as the metallothionein promoter, or an AAV Rep78 insensitive homologous promoter and which are capable of producing AAV Rep proteins and being useful for packaging recombinant AAV vectors containing target polynucleotides.
Identifier(s): utpatents-US5837484 (IID)
Patent No.: US5837484 (patno)
Appl. No.: 08/362608 (appno)
Subject(s): 435/69.1
435/235.1
435/320.1
435/369
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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