IL-12 inhibition of B1 cell activity
| Title: | IL-12 inhibition of B1 cell activity. |
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|---|---|---|
| Name(s): |
Genetics, Institute; Medical College of Ohio, assignee Metzger, Dennis W., inventor Van, Victor H., inventor |
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| Type of Resource: | text | |
| Genre: | patent | |
| Publisher: | United States Patent and Trademark Office | |
| Other Date: | Date Filed: 1995-02-02 | |
| Date Issued: | 1997-09-09 | |
| Physical Form: | application/pdf | |
| Extent: | 28 p. | |
| Abstract/Description: | The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the invention relates to a method of treating a B1 cell disorder in a host, comprising administering to the host an effective therapeutic amount of IL-12. The invention further encompasses a method of screening for substances (e.g., proteins, peptides, small molecules) which enhance or suppress the inhibition of B1 cell activity by IL-12. The invention also relates to a substance identified by the methods of screening for a substance which enhances or suppresses IL-12 inhibition of B1 cell activity. | |
| Identifier(s): |
utpatents-US5665347 (IID) Patent No.: US5665347 (patno) Appl. No.: 08/382658 (appno) |
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| Subject(s): |
424/85.2 514/3.8 514/4.3 514/7.3 514/16.6 514/17.5 514/17.9 514/19.6 |
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| Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
| Location: | University of Toledo Digital Repository | |
| Rights Statement: | No Copyright - United States | |
| In Collections: |