Histamine H3 -receptor antagonists and therapeutic uses thereof
| Title: | Histamine H3 -receptor antagonists and therapeutic uses thereof. |
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|---|---|---|
| Name(s): |
The University of Toledo; Gliatech, Inc.;, assignee Durant, Graham J., inventor Khan, Amin M., inventor Tedford, Clark E., inventor |
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| Type of Resource: | text | |
| Genre: | patent | |
| Publisher: | United States Patent and Trademark Office | |
| Other Date: | Date Filed: 1993-10-29 | |
| Date Issued: | 1996-01-23 | |
| Physical Form: | application/pdf | |
| Extent: | 24 p. | |
| Abstract/Description: | The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H3 -receptor antagonists. Such compounds have affinity for histamine H3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants. | |
| Identifier(s): |
utpatents-US5486526 (IID) Patent No.: US5486526 (patno) Appl. No.: 08/145903 (appno) |
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| Subject(s): |
514/319 514/326 514/397 546/203 546/210 548/314.7 |
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| Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
| Location: | University of Toledo Digital Repository | |
| Rights Statement: | No Copyright - United States | |
| In Collections: |