Polymers containing cross-linked azo bonds, which polymers are useful for releasing therapeutic agents into the lower gastrointestinal tract

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Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or are transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine. In particular, the polymers contain divinylazobenzene compounds of the formulae ##STR1## wherein R1 and R2 are independently selected from the group consisting of H, (except that R1 and R2 are not both H), Cl, Br, I, NO2, NH2, RO, ArO, COOH or salts thereof, COOR, COOAr, CHO, COR, SO3 H or salts thereof, R or Ar and wherein R is alkyl of up to 18 carbon atoms and Ar is mono- or bicyclic aryl of up to 15 carbon atoms.

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Abstract/Description:	Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or are transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine. In particular, the polymers contain divinylazobenzene compounds of the formulae ##STR1## wherein R1 and R2 are independently selected from the group consisting of H, (except that R1 and R2 are not both H), Cl, Br, I, NO2, NH2, RO, ArO, COOH or salts thereof, COOR, COOAr, CHO, COR, SO3 H or salts thereof, R or Ar and wherein R is alkyl of up to 18 carbon atoms and Ar is mono- or bicyclic aryl of up to 15 carbon atoms.
Subject(s):	514/10.9 514/5.9 514/10.3 514/11.6 514/54 514/56 514/150 514/151 514/568 514/772 514/778 514/960 514/961 514/962 514/963 514/964 534/573 534/843 534/DIG.3
Date Issued:	1991-07-16

Title:	Polymers containing cross-linked azo bonds, which polymers are useful for releasing therapeutic agents into the lower gastrointestinal tract.
Name(s):	Medical College of Ohio; Bowling Green State University, assignee Saffran, Murray, inventor Neckers, Douglas C., inventor
Type of Resource:	text
Genre:	patent
Publisher:	United States Patent and Trademark Office
Other Date:	Date Filed: 1988-08-12
Date Issued:	1991-07-16
Physical Form:	application/pdf
Extent:	14 p.
Abstract/Description:	Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or are transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine. In particular, the polymers contain divinylazobenzene compounds of the formulae ##STR1## wherein R1 and R2 are independently selected from the group consisting of H, (except that R1 and R2 are not both H), Cl, Br, I, NO2, NH2, RO, ArO, COOH or salts thereof, COOR, COOAr, CHO, COR, SO3 H or salts thereof, R or Ar and wherein R is alkyl of up to 18 carbon atoms and Ar is mono- or bicyclic aryl of up to 15 carbon atoms.
Identifier(s):	utpatents-US5032572 (IID) Patent No.: US5032572 (patno) Appl. No.: 07/231491 (appno)
Subject(s):	514/10.9 514/5.9 514/10.3 514/11.6 514/54 514/56 514/150 514/151 514/568 514/772 514/778 514/960 514/961 514/962 514/963 514/964 534/573 534/843 534/DIG.3
Held by:	United States Patent and Trademark Office (USPTO) Public Search Facility
Location:	University of Toledo Digital Repository
Rights Statement:	No Copyright - United States
In Collections:	University of Toledo U.S. Patents