Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin
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Abstract/Description: | Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or ?3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin. |
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Subject(s): | 514/10.9 514/15.4 514/21.1 514/21.7 514/807 530/315 930/21 930/150 930/260 |
Date Issued: | 1983-01-04 |
Title: | Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin. |
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Name(s): |
Medical College of Ohio; The Trustees of Columbia University, assignee Manning, Maurice, inventor Sawyer, Wilbur H., inventor |
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Type of Resource: | text | |
Genre: | patent | |
Publisher: | United States Patent and Trademark Office | |
Other Date: | Date Filed: 1981-03-24 | |
Date Issued: | 1983-01-04 | |
Physical Form: | application/pdf | |
Extent: | 11 p. | |
Abstract/Description: | Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or ?3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin. | |
Identifier(s): |
utpatents-US4367225 (IID) Patent No.: US4367225 (patno) Appl. No.: 06/247008 (appno) |
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Subject(s): |
514/10.9 514/15.4 514/21.1 514/21.7 514/807 530/315 930/21 930/150 930/260 |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
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