Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin

Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or ?3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin.
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Abstract/Description: Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or ?3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin.
Subject(s): 514/10.9
514/15.4
514/21.1
514/21.7
514/807
530/315
930/21
930/150
930/260
Date Issued: 1983-01-04
Title: Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin.
Name(s): Medical College of Ohio; The Trustees of Columbia University, assignee
Manning, Maurice, inventor
Sawyer, Wilbur H., inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 1981-03-24
Date Issued: 1983-01-04
Physical Form: application/pdf
Extent: 11 p.
Abstract/Description: Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or ?3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin.
Identifier(s): utpatents-US4367225 (IID)
Patent No.: US4367225 (patno)
Appl. No.: 06/247008 (appno)
Subject(s): 514/10.9
514/15.4
514/21.1
514/21.7
514/807
530/315
930/21
930/150
930/260
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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