Preparation of piperidinyl-alkyl-benzamides
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Abstract/Description: | New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula ##STR1## The hydrochlorides which exemplify the salts, have the general formula ##STR2## In the foregoing formulas R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy or trifluoromethyl, n is 1, 2 or 3 when R is methoxy but is otherwise 1, and x is 1, 2 or 3. The hydrochloride salts of the benzamides according to the invention can be produced by the reactions illustrated below: ##STR3## Wherein R, n and x have the meanings set forth above and Y can be --Cl, --F, or --OCH3. |
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Subject(s): | 546/233 514/935 |
Date Issued: | 1977-07-12 |
Title: | Preparation of piperidinyl-alkyl-benzamides. |
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Name(s): |
The University of Toledo, assignee Roll, William D., inventor |
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Type of Resource: | text | |
Genre: | patent | |
Publisher: | United States Patent and Trademark Office | |
Other Date: | Date Filed: 1976-02-23 | |
Date Issued: | 1977-07-12 | |
Physical Form: | application/pdf | |
Extent: | 4 p. | |
Abstract/Description: | New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula ##STR1## The hydrochlorides which exemplify the salts, have the general formula ##STR2## In the foregoing formulas R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy or trifluoromethyl, n is 1, 2 or 3 when R is methoxy but is otherwise 1, and x is 1, 2 or 3. The hydrochloride salts of the benzamides according to the invention can be produced by the reactions illustrated below: ##STR3## Wherein R, n and x have the meanings set forth above and Y can be --Cl, --F, or --OCH3. | |
Identifier(s): |
utpatents-US4035373 (IID) Patent No.: US4035373 (patno) Appl. No.: 05/660652 (appno) |
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Subject(s): |
546/233 514/935 |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
In Collections: |