sGCa1 inhibiting compositions

The present invention provides materials and methods useful to treat various sGCa1-expressing cancers. Materials include peptides which interfere with sGCa1's pro-survival functions, thereby resulting in apoptosis of sGCa1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
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Abstract/Description: The present invention provides materials and methods useful to treat various sGCa1-expressing cancers. Materials include peptides which interfere with sGCa1's pro-survival functions, thereby resulting in apoptosis of sGCa1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
Subject(s): A61K38/04
A61K31/7048
A61K38/06
A61K38/07
A61K38/08
A61K38/10
C07K5/083
C07K5/103
C07K5/107
C07K5/11
C07K7/06
C07K7/08
C12N9/88
A61K38/00
Date Issued: 2016-04-05