University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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Materials and methods for isolating IgA immunoglobulins
The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG.
Materials and methods related to sodium/potassium adenosine triphosphase and cholesterol
This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.
Materials and methods useful to induce cell death via methuosis
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
Materials and methods useful to induce vacuolization, cell death, or a combination thereof
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
Materials related to sodium/potassium adenosine triphosphatase and Src
This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.
Mechanical assist device for inserting catheters
The application discloses a mechanical assist device for the insertion of a catheter unit into the vein of a patient. The device includes a needle unit, a catheter unit, and a handle member having at least one strut member which engages the catheter unit. The strut member is manually displaced such that the catheter unit is slideably displaced over the needle unit.
Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious parent drug compound so as to retain efficacy while re-directing a preferred route and rate of the parent drug compound's metabolism to an inactive or very weakly active and non-toxic metabolite are disclosed. The chemical arrangement is wherein f is a phenyl, substituted aryl or heteroaryl system that is already present in the parent drug compound or is specifically added to the parent drug compound via a metabolically stable connection;R is an alkyl or alkene containing chain either branched or unbranched from 0 to 10 carbons that is already present in the parent drug compound or is added to the parent drug compound via a metabolically stable connection to f;X is a carboxyl, sulfoxyl or phosphatyl function that is specifically added to the parent drug compound via a metabolically stable connection to R; and,R' is an added alkyl, alkenyl or aralkyl group either branched or unbranched containing from 1 to 10 carbons, or is a structural element already present as an inherent portion of the parent drug compound.
Method for controlling axial shifting of rolls
A system for controlling axial shifting of working rolls on a rolling mill is provided, and more particularly, a control system method which includes monitoring sensors for the rolling mill, processing information and calculating the non-all statical friction condition for the contact surfaces of the rolls on a central processing unit, and implementing the axial shifting of the working rolls on a hydraulic system. The purposes of roll shifting are primarily to control the strip shape and crown by improving the bending roll effect, to reduce the edge drop of the strip, and to maintain the uniform wear and thermal crown of the working rolls. In order to minimize or eliminate the scarring and scotch marks caused by axial shifting of the rolls, the contact zone must be kept in a non-all statical friction state. The non-all statical friction condition may be met by controlling the shifting velocity. In the control system of the present invention, the shifting distance of the roll and the shifting velocity of the cylinder are controlled in a closed loop system. Because the setting accuracy when shifting rolls directly influences the strip shape quality, the closed loop of roll position is taken as the outer loop of the system and shifting velocity is established as the inner loop. Displacement transducers and velocity transducers are used to generate control signals base on the actual shifting distance and actual shifting velocity.
Method for determining properties of optically isotropic and anisotropic materials
A method for optically determining the ratio of Poisson's ratio to modulus of elasticity for optically isotropic and optically anisotropic transparent materials and then for determining the stress-optical constants for such materials. A collimated monochromatic light beam is directed at the tip of a crack in a loaded thin plate specimen of the material and the diameters of the resulting transmitted and reflected caustics are measured at points equidistant from the specimen. The light beam also is directed to an uncracked region in a loaded thin plate specimen of the material and the number of displaced fringe reflected on a screen are counted for a predetermined change in loading. The ratio of Poisson's ratio to modulus of elasticity and the stress-optical constants are determined from the thickness of the specimen, the displaced fringe count, the wavelength of the light beam and the ratio of the caustic diameters.
Method for determining stress-optical constants of optically isotropic and anisotropic materials
A method for optically determining the stress-optical constants of optically isotropic and anisotropic materials. A collimated beam of monochromatic light is directed at the tip of a crack in a thin plate specimen under plane-stress from a direction substantially perpendicular to the surface of the specimen and to the direction of the stress. Reflected and transmitted stress-optical constants are determined from a ratio of the diameters of transmitted and reflected caustics from the specimen and the known Poisson's ratio and modulus of elasticity for the specimen.
Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
An HDL cholesterol level inducing compound and a method of administering the compound having the structural formula I. ##STR1## wherein n is 1 or 2;R1 is a heteroaromatic substituent independently selected from a five-membered heteroaromatic ring having at least one N heteroatom, a six-membered heteroaromatic ring having at least one N heteroatom, or a fused ring system having at least one five-membered heteroaromatic ring having at least one N heteroatom;R2 is independently selected from --H or phenyl; andR3 is independently selected from --H, --CH3, --OH, phenyl, phenyl substituted with Cl, OCH3, CH3, or F, fused phenyl ring system, or six-membered heteroaromatic ring having at least one N heteroatom.
Method for increasing the hydrogen:carbon ratio of an organic compound
A method for increasing the hydrogen:carbon ratio of an organic compound is disclosed. The organic compound can be one having any of the following functions: hydroxyl, carbonyl, epoxide, acetal, ketal, hemiacetal and hemiketal. The method involves introducing the organic compound and a silicon hydride into a liquid which is either chemically inert or acidic and introducing BF3 into the liquid to produce a reaction product having a higher hydrogen:carbon ratio than the starting organic compound. Examples of organic compound starting materials disclosed include undecanal, benzaldehyde, p-methylbenzaldehyde, p-chlorobenzaldehyde, p-methoxybenzaldehyde, p-cyanobenzaldehyde, p-nitrobenzaldehyde, 2-undecanone, cyclohexanone, 2-methylcyclohexanone, adamantanone, p-cyanoacetophenone, fluorenone, 1-naphthaldehyde, p-nitroacetophenone, fructose and cotton. The use, as the silicon hydride, of triethylsilane, (R)-(+)-1-naphthylphenylmethylsilane, dimethylethylsilane, phenylneopentylmethylsilane, and of tri-n-hexylsilane is disclosed, while methylene chloride is disclosed as the liquid in which the reaction is conducted.
Method for measurement of physical characteristics of crystals
A method and apparatus to simultaneously measure the diffraction resolution and mosaic spread of macromolecular crystals, are described. The method includes minimizing contributions of an x-ray beam to any reflection angular widths in the crystal, rapidly measuring multi reflection profiles in the crystal over a wide resolution range, evaluating and deconvoluting the Lorentz effect and beam contributions, and determining the direction in which the crystal is most perfect.
Method for modulating pigmentation by targeting BET bromodomain proteins
Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein inhibitors, such as JQ1, are used to reduce pigmentation, promote cell cycle arrest, inhibit the expression of TYR, TRP1, and DCT proteins, inhibit the expression of TYR mRNA, and suppress melanocyte proliferation.
Method for quantitative measurement of gene expression for identifying individuals at risk for bronchogenic carcinoma
A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed.
Method for selecting a treatment for non-small cell lung cancer using gene expression profiles
The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.
Method for the selective removal of acyl-functionality attached to the 2'-hydroxy-group of paclitaxel-related derivatives
A method for removing acyl-groups appended by an ester linkage to the 2'-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2',7-bis-Monochloroacetylpaclitaxel analogs are converted to their corresponding 7-monochloroacetyl derivatives by treatment with alcohol under non-acidic conditions
Method for treating bioorganic and wastewater sludges
The method of treating wastewater or bioorganic sludges containing odor, animal viruses, pathogenic bacteria, and parasites to produce a bioactive but stabilized product that is useful as a soil substitute or as a fertilizer which can be applied directly to lands which consists essentially of the following steps: mixing said sludge with at least one alkaline material, wherein the amount of added material mixed with said sludge is sufficient to raise the pH of said mixture to pH 12, and raise the conductivity to disinfect and stabilize the sludge, and adding green waste at different process locations so that a biological action occurs converting the greenwaste into a soil-like granular product with improved odor over that of the treated municipal sludge alone or a composted greenwaste alone.

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