University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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Imines of porphyrins, of porphyrin derivatives, and of related compounds, and pharmaceutical compositions containing such imines
Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth below: ##STR1## In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R' and R"" are methyl, and R1 through R8 are ethyl.
Improving efficacy of cancer therapy
Embodiments of the invention provide a method of improving the efficacy of an anti-cancer therapy and a method of treatment of cancer by normalizing angiogenesis in cancer. By enhancing the cell signaling pathway via a TRPV4 receptor in tumor endothelial cells, either by a TRPV4 agonist or by increasing the expression of TRPV4 in the tumor endothelial cells, the tumor endothelial cells behave normally and form normal angiogenic network for better anti-cancer therapy to the tumors.
Inhibitors of ERCC1-XPF and methods of using the same
Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
Injectable, biodegradable bone cements and methods of making and using same
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.
Injectable, biodegradable bone cements and methods of making and using same
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.
Insertion assembly for minimally invasive spinal surgery
A telescopic insertion assembly is configured to insert a pedicle screw into a vertebral body. The insertion assembly includes an attachment fixture having one end configured to mate with the pedicle screw and another end having a ridged portion. A center tube is provided having one end slidably attached to the attachment fixture and another end having an internally ridged portion. A telescoping member has one ridged end configured to slidably attach to the center tube and another end having a yoke. The telescoping member is configured to extend the yoke to different distances from the center tube. An alignment member is configured to hingeably attach to the yoke of the telescoping member. The alignment member is configured to rotate from a first position to a second position. The second position of the alignment member is above a top surface of a patient's skin.
Instrument for measuring the range of motion associated with a human body joint
The present invention relates to an instrument for measuring the range of angular displacement associated with two human body portions connected to a common joint. The instrument includes two pivotally connected, elongate rods, and separate supports for supporting each of the rods on a respective one of the body portions in spaced relationship with the body portion. Each of the supports includes a pair of ball and socket assemblies which are mounted on the respective body portions in spaced relation to one another. The ball of each ball and socket assembly has an aperture formed therethrough for receiving the associated elongate rod. Such a support arrangement enables the body portions to be rotated about the common joint without affecting the natural movements of the body portions. An encoder is utilized to pivotally connect the two elongate rods and to generate an electrical output signal representing the relative angular position between the two rods. A counter and display circuit is responsive to the encoder output signal for determining the change in angular position between the two rods and displaying this value in terms of angular degrees.
Integrated magneto-optic modulator/compensator system, methods of making, and methods of using the same
Described herein is an integrated Faraday modulator and Faraday compensator (IFMC) system. Further described are methods of making an IFMC system, methods of customizing an IFMC system for a specific application, and methods of optimizing an IFMC system for a specific application. Further described is a robust 3D Finite Element Model (FEM) for designing and optimizing an IFMC system. Further described are optical instruments comprising an integrated Faraday modulator and Faraday compensator requiring only one optical crystal.
Integrated magneto-optic modulator/compensator system, methods of making, and methods of using the same
Described herein is an integrated Faraday modulator and Faraday compensator (IFMC) system. Further described are methods of making an IFMC system, methods of customizing an IFMC system for a specific application, and methods of optimizing an IFMC system for a specific application. Further described is a robust 3D Finite Element Model (FEM) for designing and optimizing an IFMC system. Further described are optical instruments comprising an integrated Faraday modulator and Faraday compensator requiring only one optical crystal.
Integrated photoelectrochemical cell and system having a liquid electrolyte
An integrated photoelectrochemical (PEC) cell generates hydrogen and oxygen from water while being illuminated with radiation. The PEC cell employs a liquid electrolyte, a multi-junction photovoltaic electrode, and a thin ion-exchange membrane. A PEC system and a method of making such PEC cell and PEC system are also disclosed.
Internal staged permeator for fluid separation
A gas separation membrane device comprising an internally staged permeator containing a three dimensional array of hollow fiber membranes grouped into multiple sets in intimate contact with each other is described. The incorporation of the internally staged permeator, particularly, the arrangement of the multiple sets of fiber membranes in intimate contact with each other, results in improved efficiency of the device, especially for feed streams or membrane types that lead to high permeate flow rate that result in excessive shellside pressure drops.
Intracavitary radiation system
A system is provided for use in brachytherapy where a central tube permits passage of a radioactive source therethrough to deliver a prescribed dosage of radiation. One or more balloons are coaxially positioned around the central tube. At least one balloon includes one or more peripheral tubes extending along at least a portion of the balloon. The peripheral tube is also attached to the high dose rate brachytherapy unit in order to permit passage of a radioactive source therethrough.
Ionically crosslinked polyelectrolytes as underwater adhesives as controlled release vehicles
Underwater adhesive materials, methods of making the same, and methods of using the same are described.
Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging
A compound of formula (I): ##STR1## wherein, R1 is independently selected from methyl and ethyl and R2 is independently selected from hydrogen, alkyl, and substituted alkyl. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue. The present invention also relates to a method of administering the second sphere contrast agent.
Knee joint mechanism for knee disarticulation prosthesis
An improved four-bar knee joint mechanism for use in knee disarticulation prosthesis is shown, including a coupler link forming a negative angle with the horizontal when said knee joint mechanism is in its stance position, an anterior link, a fixed link in a horizontal position when said knee joint is in the extended or stance position, and a posterior link, the dimensions of the links and the angle the coupler link makes with the horizontal being chosen to optimize the instant center of the mechanism.
Lateral fixation assembly for spinal column
A lateral fixation assembly engages vertebrae in a spinal column. The lateral fixation assembly includes a housing having a first rod and a second rod supported thereon. The first rod is adapted to be secured to a first vertebra in the spinal column and is fixed in position relative to the housing. The second rod is adapted to be secured to a second vertebra in the spinal column and is movable relative to the housing. Respective pluralities of such first and second rods may be provided. Staples having varying thicknesses may be provided to facilitate the installation of the lateral fixation assembly on the vertebrae in the spinal column. A temporary blocking device can be used to prevent relative movement of the movable rod during the installation of the lateral fixation assembly.
Layered electrodes with inorganic thin films and method for producing the same
A method for the preparation of layered electrodes, including ultramicroelectrodes, through application of a thin film coating of an inorganic material to a conductor by use of chemical vapor deposition. The chemical vapor deposition techniques of the present invention provide a layered electrode that is efficiently and effectively manufactured in a standard reaction chamber at atmospheric pressure. The preferred conductors are carbon fibers and foams, and metal (platinum or gold) wires, meshes and foams. The precursors for the thin film deposition include those that yield thin-films of insulators, semiconductors, metals, and superconductors. During the chemical vapor deposition process, a thin film coating is formed on the conductor by the pyrolytic decomposition of the precursor vapor at the surface of the heated conductor. The hardness and rigidity of the thin film layer imparts durability and structure to the fragile and flexible conductors without significantly increasing the size of the device. The variable parameters in the deposition process are monitored and controlled so that the desired thickness of thin film coating will be obtained.
Lime-fly ash-aggregate-sludge paving material
A composition and method for producing an improved lime-fly ash-aggregate is disclosed. The composition is prepared by mixing together lime, flyash, graded aggregate, adding water, and from 0.5 to 4 percent, based on total dry weight, of sludge from a water treatment plant. The mixture is placed on top of a prepared subgrade, spread uniformly, and compacted to a high degree of relative density to provide the main load-carrying component of a road, airport runway, parking lot or the like.
Linear derivatives of arginine vasopressin antagonists
Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula A--CH2 CO--D--Tyr(R)--Phe--Y--Asn--T--U--Z--Qwherein A is a-adamantyl, cyclohexyl, cyclopentyl, 1-mercaptocyclohexyl, 1-mercaptocyclopentyl, 1-ethyl-1-mercaptopropyl, yclohexylmethyl, cyclopentylmethyl, methyl, isopropyl, tert-butyl or phenyl; R is alkyl of 1-4 carbon atoms; Y is Val, Ile, Thr, Ala, Lys, Cha, Nva, Met, Nle, Orn, Ser, Asn, Gln, Phe, Tyr, Gly, Abu or Leu; T is Pen, Abu, Orn, Oys, Arg, Ala, Cha or Thr; U is Pro, Arg, Lys or Orn or a single bond; Z is (d-or L-) Arg, Orn or Lys and Q is Gly(NH2), Arg (NH2), Orn(NH2), Lys (NH2), (D- or L-)Ala(NH2), Ser(NH2), Val(NH2), Phe(NH2), Ile(NH2), Thr(NH2), Pro(NH2), Tyr(NH2), NH2, OH, NHR, NGbzl, NH(CH2)p NH2 or NH(CH2)p OH, wherein R is as above and p is an integer from 2 to 6. Compounds wherein T is Cys have similar activity.
Liquid crystal flat panel color display with surface plasmon scattering
A flat panel color display is provided in which white collimated light incident on a light coupling means having a metal layer and a liquid crystal layer formed on a surface of the coupling means produces a colored spot of light at the interface of the metal layer and liquid crystal layer through the excitation of surface plasmons. The present invention utilizes the color selective scattering of incident white light by surface plasmons and includes a coupling device, such as a high index glass prism, with a metal film layer and a liquid crystal layer formed on the coupling device. Surface plasmon waves can be generated at a negative dielectric (metal layer)-positive dielectric (liquid crystal layer) interface when the dispersion relationship is satisfied. The incident white light includes photons which have frequencies approximately equal to the plasmon resonance, and such photons are strongly scattered. Photons having a frequency other than the plasmon resonance will be totally reflected. The dispersion relationship of the metal-liquid crystal interface depends on the dielectric constant of the metal, which is not typically variable, and the dielectric constant of the liquid crystal, which is variable. An external voltage control/modulator may be used to vary the dielectric constant of the liquid crystal, thereby controlling the plasmon resonance condition and the frequencies (color) of the scattered photons.

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