University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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Cyclic beta-sheet peptides useful as apoptotic/cytotoxic cancer agents
Peptides and pharmaceutical compositions of matter useful as cytotoxic compositions particularly for, but not limited to, treatment of cancers, that includes a synthetic peptide whose amino acid sequence is different from an initial loop of cobra cardiotoxin.
Derivatives of arginine vasopressin antagonists
Compounds acting as antagonists of the an The invention described herein was made in the course of work under a grant or award from the Department of Health and Human Services.
Diels alder adducts of vinyl porphyrins
Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the structures of Formulas 1, 2, 3 and 4, below: ##STR1## where R1, R2, R3 and R4 can be the same or different, and each is methyl, ethyl or an amino acid moiety which is a part of an amide produced by reaction between an amine function of a naturally occurring amino acid and a carbonyl function of the adduct, R5, R6 and R7 can be the same or different, and each is ethyl or an amino acid moiety which is a part of an amide produced by reaction between an amine function of a naturally occurring amino acid and a carbonyl function of the adduct, M comprises a metal cation, e.g., Sn or Zn, that is complexed with two of the nitrogens of the adduct, and R8 is an alkyl group other than t-butyl having from one to four carbon atoms. The use of the adducts and complexes in PHD is also disclosed.
Dispensing system having weight dependent control means
The present invention relates to a dispensing system for supplying and administering a metered dose of a material to an animal subject wherein the amount of the material supplied is a function of the weight of the subject. The delivery system includes a scale for determining the weight of the subject and for generating a weight control signal representing the weight of the subject. A microcomputer is responsive to the weight control signal and a preprogrammed weight conversion factor for generating a delivery control signal to a delivery unit. The delivery unit is responsive to the delivery control signal for supplying a predetermined amount of the material to the subject. The predetermined amount represents an amount which is a function of the weight of the subject of the weight conversion factor.
Efficient resonant self-heating battery electric circuit
A circuit for heating an energy storage device is disclosed. The circuit includes a switching device having a closed state and an open state. The circuit also includes a storage circuit for storing energy. The storage circuit has a resonating frequency. A controller is provided for operating the switching device. In operation, energy is transferred from the energy storage device to the storage circuit while the switching device is in the open state, and returned from the storage circuit to the energy storage device while the switching device is in the closed state. This energy transfer causes warming of the energy storage device.
Electroless plating of a metal layer on an activated substrate
A method of electroless plating at least one homogeneous metal coating in a predetermined pattern on a solid substrate surface having pendant hydroxy groups. The method includes the steps of providing a first monatomic metal layer in a predetermined pattern on the solid substrate surface having pendent hydroxy groups and then immersing the solid substrate surface in a bath containing a chemical reducing agent to build up the at least one homogeneous metal coating only on the monatomic metal layer.
Electromagnetic polymer composite material for anti-fouling effect
The antifouling coating is a composite material consisting of fluorinated electroactive bipolymers and magnetic particles. This composite material is coated on a solid surface to make a smooth durable grassy coating. The coating generates electrical current when an electrolytic liquid flows over it, which prevents bacterial cells from attaching to the surface. It prevents virus and protein attachment. It also prevents chemical corrosion of a surface. The composite material itself, and the antifouling method that uses fluoride compounds and electrical current that is generated by the fluid flow are disclosed for a patent. The composite material can be applied to medical devices, biomedical devices, industrial equipment, ship's hulls, food processing equipment, food processors, drinking water distribution systems, and home electrical appliances.
Electronic circuit for measuring series connected electrochemical cell voltages
An electronic circuit for measuring voltage signals in an energy storage device is disclosed. The electronic circuit includes a plurality of energy storage cells forming the energy storage device. A voltage divider circuit is connected to at least one of the energy storage cells. A current regulating circuit is provided for regulating the current through the voltage divider circuit. A voltage measurement node is associated with the voltage divider circuit for producing a voltage signal which is proportional to the voltage across the energy storage cell.
Energy storage system with ultracapacitor and switched battery
An energy storage system for a vehicle includes an ultracapacitor that is electrically coupled in parallel with a battery through a diode connected in series with the battery. The ultracapacitor delivers the energy required for all high current surges that occur during engine start, acceleration, and regeneration. The battery is used only to assist with longer duration, high energy loads, such as accessory loads when an engine of the vehicle is not running. In other words, the battery conducts only during longer and less-frequent pulses and, therefore, does not have to withstand high-power pulses.
Epithiolone analogues
Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain.
Exercise device
An exercise device for the lower extremities that can be mounted on a support and has a frame having a first leg and a second leg. The first and second legs have a first end and a second end. The first end of the first and second legs are pivotally connected. A cylinder is connected to the first and second legs for providing resistance. The resistance is produced when the second end of the second leg is moved in a direction toward the first leg. A resilient spring is connected to the second leg. The resilient spring moves the second end of the second leg away from the first leg. A control valve is operatively connected to the cylinder for varying the resistance of the cylinder. A pad is positioned on the second end of the first leg. The pad is positioned to be engaged by the user to pivot the second end of the first leg towards said second leg against the resistance provided by the cylinder. The resilient spring moves the second end of the first leg away from the second leg to return the first leg to the original position. The user repetitively moves the second end of the first leg towards the second leg to exercise the lower extremity.
Exhaust gas purification catalysts and methods of making the same
A catalyst and its use for the abatement of carbon monoxide and unburned hydrocarbons in the exit stream of a combustion device, such as an automobile and spray paint booths are disclosed.
Expandable inter-vertebral cage and method of installing same
An inter-vertebral cage for use in repairing a damaged inter-vertebral disc includes a plurality of cage sections and a hinge element that connects adjacent ones of the cage sections together for relative movement. The hinge elements automatically urge the cage sections to move from an extended orientation to an installed orientation.
Expandable intramedullary nail for the fixation of bone fractures
The present invention relates to an improved expandable intramedullary nail for the fixation of bone fractures. The nail includes an elongate sleeve having one end adapted to be inserted within the medullary cavity of the bone. The one end of the sleeve is formed of a predetermined maximum retracted diameter to permit the insertion of the one end within the bone cavity. A plurality of circumferentially spaced, radially expandable elements are carried by the one end of the sleeve. The elements are radially movable from a first, retracted position wherein the elements define a first diameter to a second, expanded position wherein the elements define a second diameter greater than the predetermined maximum retracted diameter and the first diameter. In accordance with the present invention, when the elements are in the expanded position, the elements provide at least two support points at the second diameter and axially spaced along the sleeve for engagement with the inner wall of the bone cavity. A camming member is carried by the one end of the elongate sleeve for moving the elements from the retracted position to the expanded position. An actuator is located at the other end of the sleeve and is coupled to operate the camming member for controlling the radial position of the elements.
Expanding intramedullary nail
An intramedullary nail for the fixation of bone fractures is formed of two slidably engaging elongate members. One of the members includes an articulated channel which serves to bend the other member to form an expanding end region within the bone cavity to achieve fixation therein.
Expanding multi-lumen applicator operating within a balloon
A brachytherapy apparatus includes a distal support member and a proximal support member movable relative to the distal support member. The apparatus includes a plurality of elongate treatment members having distal first locations coupled to the distal support member, proximal second locations coupled to the proximal support member, and pathways between the proximal second locations and the distal first locations adapted to receive one or more radiation sources. Each of the treatment members is movable between a generally straight configuration and a curvilinear configuration. An expandable member encloses and provides a spatial volume for the plurality of the treatment members and is adjustable between a contracted configuration and an expanded configuration.
Fixation assembly having an expandable insert
A fixation assembly having one or more insertions member that include one or more expandable and retractable anchoring inserts positioned along at least a portion of the insertion member and methods of use thereof are disclosed.
Flexible photovoltaic cells having a polyimide material layer and method of producing same
A photovoltaic cell is fabricated onto a polyimide film using an unbalanced RF magnetron sputtering process. The sputtering process includes the addition of 0.05% to 0.5% oxygen to an inert gas stream. Portions of the photovoltaic cell are exposed to an elevated temperature CdCl2 treatment which is at or below the glass transition temperature of the polyimide film.
Gene and method for production of a 40-45-kDa IgA binding protein
The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG.
Gene and method for production of an IgA binding protein
The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG.

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