University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

The University of Toledo, Technology Transfer Website

Pages

Xenoantigen-displaying anti-cancer vaccines and method of making
Compositions, methods of making, and methods of using, xenoantigen-displaying anti-cancer vaccines are described.
Vortex generation for control of the air flow along the surface of an airfoil
Apparatus for generating vortices to control the flow of air across a airfoil of an aircraft includes a series of pressure active regions arranged along the leading edge of the airfoil. The pressure active regions include spaced apart valves connected to a source of vacuum, a controller for activating the valves, and sensors for sensing air pressure. The controller is configured to activate the valves in response to the pressure sensed by the sensors, wherein the spaced apart valves are connected to a source of pressurized air as well as to the source of vacuum.
Venting-membrane system to mitigate blast effects
A venting-membrane system for mitigating blast pressure generated from a blast force on a wall structure. The venting-membrane system having a framework including a plurality of parallel structural members defining a wall structure having an interior surface and an exterior surface. At least one inflatable enclosure attached to the interior surface of the wall; and at least one inflatable enclosure attached to the exterior surface of the wall wherein the at least one inflatable enclosure attached to the interior surface of the wall is in communication with the at least one inflatable enclosure attached to the exterior surface of the wall.
Variable height vertebral body replacement implant
A variable height vertebral body replacement implant used in corpectomy surgery to provide support in place of a removed or damaged vertebrae, and contain and compact bone graft material.
Use of purpurins, chlorins and purpurin- and chlorin-containing compositions
The treatment of blood and other body fluids and tissues, the detection of tumors and the treatment of patients is disclosed. The treatment and detection involve the use of families of chlorins, families of purpurins and families of metal complexes of chlorins and purpurins. The purpurins and their metal complexes have the structures of FIGS. 1 , 7, 14-18, 29-38, 44-48 and 54-58 of the attached drawings. The chlorins and their metal complexes have the formulas of FIGS. 2 , 8, 19, 20, 22, 23, 24, 25, 27, 28, 39, 40, 42, 43 and 49-53 of the attached drawings. Solutions of the purpurins, of the foregoing and other chlorins and of the metal complexes which are physiologically acceptable for intravenous administration are also disclosed, as are emulsions or suspensions of the solutions. The solvent for the solutions can be a product of the reaction of ethylene oxide with castor oil.Families of purpurins, chlorins and metal complexes which can be detected by nuclear magnetic resonance or by an instrument that detects ionizing radiation are also disclosed. These compounds have the formula of one of FIGS. 1 , 2, 7, 8, or 14-58 and a structure which is enriched in an atom that can be detected by nuclear magnetic resonance, e.g., 13 C or 15 N, or by an instrument that detects ionizing radiation, e.g., 14 C or 131 I.
Use of photodynamic therapy to treat prostatic tissue
The present invention provides a method for diagnosing or treating prostatic tissue in a human or animal patient which comprises sensitizing the prostatic tissue with an effective amount of a photosensitive composition which accumulates in the prostatic tissue and exposing the sensitized tissue to a source of light energy for a predetermined time and intensity sufficient to cause cellular and/or tissue function of the sensitized prostatic tissue to diminish or cease.
Use of acyl-homoserine lactone derivatives as anti-thrombotic agents
Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit platelets from becoming hypersensitive, and/or to prevent thrombosis, are described.
Unfiltered radiation therapy
This is a new technique in IMRT and 3D conformal gamma radiation dose delivery using a linear accelerator with no flattening filter. The technique improves patient radiation therapy by reducing radiation scattered to surrounding normal tissue and reducing electron contamination. It increases dose rate to shorten treatment time. Linear accelerators have for decades come with a photon flattening filter to make the photon profile of planar fluence to make the dose distribution more uniform. These filters, however, resulted in fluence attenuation and contamination of the beam. Now in the age of techniques such as intensity modulated radiation therapy (IMRT) the function of the flattening filter becomes redundant. The flattening filter now merely reduces the efficiency of the beam by reducing the fluence and increasing scattered radiation. Our technique involves removal of the flattening filter for complex treatments. It uses inverse planning along with multi-leaf collimators to shape the dose distribution.
Unfiltered radiation therapy
This is a new technique of producing high energy X-rays for radiation therapy at a patient's level. The dose delivery system uses a linear accelerator with no flattening filter. The technique improves patient radiation therapy by reducing radiation scattered to surrounding normal tissue and reducing electron contamination. It increases dose rate to shorten treatment time. The flattening filter reduces the efficiency of the beam by reducing the fluence and increasing scattered radiation. This technique involves removal of the flattening filter. It uses inverse planning to shape the dose distribution.
Ultrastable silver nanoparticles
Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed.
Trunk rotation
This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and condition the muscles of the axial skeleton of the golfer in a functional posture.
Trunk rotation
This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and condition the muscles of the axial skeleton of the golfer in a functional posture.
Trunk rotation
This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and condition the muscles of the axial skeleton of the golfer in a functional posture.
Trianionic ligand precursor compounds and uses thereof in constrained geometry catalysts
Trianionic ligand precursor compounds, catalyst systems containing the precursor compounds, and uses of the precursor compounds are described. The present invention also provides constrained geometry catalysts, methods to make the constrained geometry catalysts and methods to use the constrained geometry catalysts in various reaction systems, including polymerization, metathesis reactions, and hydroamination reactions.
Treatment of cancers with A-8R peptide
The present invention provides materials and methods useful to treat various sGCa1-expressing cancers. Materials include peptides which interfere with sGCa1's pro-survival functions, thereby resulting in apoptosis of sGCa1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
Treatment of cancers with A-8R peptide
The present invention provides materials and methods useful to treat various sGCa1-expressing cancers. Materials include peptides which interfere with sGCa1's pro-survival functions, thereby resulting in apoptosis of sGCa1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
Tissue culture system
A tissue culture system for zero gravity high-density cultivation of eucaryotic cells requiring attachment to a substratum in order to differentiate is disclosed. A major component of the system is a cylindrical bottle filled with culture medium and having mounted therein a rotatable shaft. The shaft includes a plurality of collagen-treated discs projecting therefrom and at an angle to the shaft to provide the necessary attachment substratum and to impel the culture medium as the shaft is rotated. Means are provided for initial stocking of the bottle with the culture cells and for continuously supplying fresh medium to and removing waste medium from the bottle.
Tissue culture device for mass cell culture
A multiplate, cell propagation device for use in tissue culture having an elongate enclosed vessel containing a plurality of parallel, spaced apart discs secured for rotation within the vessel. The device includes a cradle-like frame for holding the discs in place during rotation thereof, with the entire frame or individual discs being removable from the vessel without disturbing other discs. Means are provided on the frame for selectively holding the discs in place.
Thermal fractionation of biomass of non-lignocellulosic origin for multiple high-quality biofuels
Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described. The products of said methods are also described.
Thermal fractionation of biomass of non-lignocellulosic origin for multiple high-quality biofuels
Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described.

Pages