University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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PPARG modulators for treatment of osteoporosis
The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.
Back contact layer for photovoltaic cells
A photovoltaic cell structure is disclosed that includes a back contact layer that includes single wall carbon nanotube elements. The single wall carbon nanotube (SWNT) back contact is in electrical communication with an adjacent semiconductor layer and provides a buffer characteristic that impedes elemental metal migration from the back contact into the semiconductor active layers. In one embodiment, the SWNT back contact includes a semiconductor characteristic and a buffer characteristic. In another embodiment, the SWNT back contact further includes a metallic characteristic.
Methods for synthesizing glycinols, glyceollins I and II, compositions of selected intermediates, and therapeutic uses thereof
Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.
Methods and devices for detecting unsaturated compounds
A sensor for detecting the presence of unsaturated compounds, the sensor comprising: a semiconductor material doped with a metal halide in electrical connection with a monitoring device.
Muscarinic agonists
Substituted 1,4,5,6 -tetrahydropyrimidine compositions, substituted 1,2,3,6 -tetrahydropyrimidine compositions and substituted 3,4,5,6 -tetrahydropyridine compositions are disclosed. They are useful for stimulating muscarinic receptors including, for example, treating the symptoms of cognitive disorders, especially impaired memory, which are associated with decreased acetylcholine synthesis and cholinergic cell degeneration.
Antibacterial surfactant/microgel formulations, methods of making and methods of using the same
Formulations having, as active agents, at least one quaternized polymeric microgel and at least one nonionic surfactant, methods of making, and methods of using are described.
sGCa1 inhibiting compositions
The present invention provides materials and methods useful to treat various sGCa1-expressing cancers. Materials include peptides which interfere with sGCa1's pro-survival functions, thereby resulting in apoptosis of sGCa1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
Photovoltaic module device
No abstract in application
Methods and benzamide compositions for producing hypotensive activity
Hypotensive pharmaceutical compositions comprising effective amounts of compounds of the formula: ##SPC1## Wherein A, B, and C are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals at least one of which is an alkoxy or a halogen radical; wherein x is a whole number from one to three, and wherein R is selected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms, together with carriers therefor, and the methods for administering said compounds.
Chopper and chopper-multiplexer circuitry for measurement of remote low-level signals
A balanced bridge chopper circuit including four metal oxide semiconductor field effect transistors (MOSFETs) is driven by a remote oscillator connected through an isolator to modulate low-voltage low-frequency input signals at their remote source into a square wave A.C. output signal that can be conducted to a common point where it is amplified and demodulated for better linear measurement of said low-voltage signals. The oscillator is connected through the isolator to the bridge circuit in such a manner that opposing pairs of the bridge transistors are simultaneously conducting. The isolator may comprise a novel photovoltaic isolation device or it may consist of an isolation transformer or of other types of electrical isolation devices. The transistors and input and output terminals for the bridge circuit are shielded and are mounted on a heat sink consisting of a thermally conducting metal plate and/or a metal oxide single crystal which is in common with the shield and/or one terminal of the low-voltage source such that all leads and terminals are maintained at a constant temperature and preferably at the same temperature as the low-voltage source. Air currents are prevented from causing thermally induced voltages within the bridge circuit by the circuit shield and in some extreme cases by the use of a hermetically sealed shield for the critical circuit elements and connections. For accurately balancing out interelectrode capacitance-coupled gate drive to low-level channel signals, a pair of variable capacitors are connected between one output terminal of the bridge circuit and the gate of each of its two adjacent transistors. The balanced bridge chopper may be produced as a monolithic planar-silicon integrated circuit in which gate-to-channel capacitance balancing is accomplished during manufacturing in place of the variable capacitors. A novel balanced input filter and trimmer capacitors between the bridge output terminals and local ground greatly reduce 60 Hz. common mode noise. In a hybrid circuit embodiment of the bridge circuit, the individual MOSFET chips forming the bridge circuit are bonded and interconnected within a hermetically sealed and magnetically transparent metal oxide single crystalline container. Multiplexing circuitry is also disclosed for driving several chopper circuits from a single oscillator and for connecting the outputs from the chopper circuits to a single amplifier and demodulator at a remote location.
Preparation of piperidinyl-alkyl-benzamides
New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula ##STR1## The hydrochlorides which exemplify the salts, have the general formula ##STR2## In the foregoing formulas R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy or trifluoromethyl, n is 1, 2 or 3 when R is methoxy but is otherwise 1, and x is 1, 2 or 3. The hydrochloride salts of the benzamides according to the invention can be produced by the reactions illustrated below: ##STR3## Wherein R, n and x have the meanings set forth above and Y can be --Cl, --F, or --OCH3.
Chopper-multiplexer system for measurement of remote low-level signals
A balanced bridge chopper circuit including four metal oxide semiconductor field effect transistors (MOSFETs) is driven by a remote oscillator connected through an isolator to modulate low-voltage low-frequency input signals at their remote source into a square wave A.C. output signal that can be conducted to a common point where it is amplified and demodulated for better linear measurement of said low-voltage signals. The oscillator is connected through the isolator to the bridge circuit in such a manner that opposing pairs of the bridge transistors are simultaneously conducting. The isolator may comprise a novel photovoltaic isolation device or it may consist of an isolation transformer or of other types of electrical isolation devices. The transistors and input and output terminals for the bridge circuit are shielded and are mounted on a heat sink consisting of a thermally conducting metal plate and/or a metal oxide single crystal which is in common with the shield and/or one terminal of the low-voltage source such that all leads and terminals are maintained at a constant temperature and preferably at the same temperature as the low-voltage source. Air currents are prevented from causing thermally induced voltages within the bridge circuit by the circuit shield and in some extreme cases by the use of a hermetically sealed shield for the critical circuit elements and connections. For accurately balancing out interelectrode capacitance-coupled gate drive to low-level channel signals, a pair of variable capacitors are connected between one output terminal of the bridge circuit and the gate of each of its two adjacent transistors. The balanced bridge chopper may be produced as a monolithic planar-silicon integrated circuit in which gate-to-channel capacitance balancing is accomplished during manufacturing in place of the variable capacitors. A novel balanced input filter and trimmer capacitors between the bridge output terminals and local ground greatly reduce 60 Hz. common mode noise. In a hybrid circuit embodiment of the bridge circuit, the individual MOSFET chips forming the bridge circuit are bonded and interconnected within a hermetically sealed and magnetically transparent metal oxide single crystalline container. Multiplexing circuitry is also disclosed for driving several chopper circuits from a single oscillator and for connecting the outputs from the chopper circuits to a single amplifier and demodulator at a remote location.
Lime-fly ash-aggregate-sludge paving material
A composition and method for producing an improved lime-fly ash-aggregate is disclosed. The composition is prepared by mixing together lime, flyash, graded aggregate, adding water, and from 0.5 to 4 percent, based on total dry weight, of sludge from a water treatment plant. The mixture is placed on top of a prepared subgrade, spread uniformly, and compacted to a high degree of relative density to provide the main load-carrying component of a road, airport runway, parking lot or the like.
Method for determining stress-optical constants of optically isotropic and anisotropic materials
A method for optically determining the stress-optical constants of optically isotropic and anisotropic materials. A collimated beam of monochromatic light is directed at the tip of a crack in a thin plate specimen under plane-stress from a direction substantially perpendicular to the surface of the specimen and to the direction of the stress. Reflected and transmitted stress-optical constants are determined from a ratio of the diameters of transmitted and reflected caustics from the specimen and the known Poisson's ratio and modulus of elasticity for the specimen.
Methods and nitro-benzamide compositions for producing tranquilizing and hypotensive activity
Simultaneously acting tranquilizing and/or hypotensive pharmaceutical compositions comprising effective amounts of compounds of the formula: wherein R is selected from the group consisting of alkyl, hydroxyalkyl, cyanoalkyl, aryl, aralykl, and hydroxyaralkyl radicals; and wherein R' is slected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms.
Methods and cyclopentyl benzamide compositions for producing depressant activity
Simultaneously acting depressants to the central nervous system and the cardiovascular system of the formula ##SPC1## Wherein R is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals; and wherein x is a whole number from 1 to 3.
N-Substituted-N'-Cycloalkyl-Nitrobenzamides
Simultaneously acting central nervous system (CNS) depressants and blood pressure depressors of the formula ##SPC1## wherein R is selected from the group consisting of alkyl, hydroxyalkoxy, cyanoalkyl, aryl, aralykl, and hydroxyaralkyl radicals and wherein R' is selected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms.
N-Cyclopentyl-N-2-Hydroxyalkyl-Ring-Substituted Benzamides
Simultaneously acting central nervous system (CNS) depressants and blood pressure depressors of the formula ##SPC1## wherein R is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals; and x is a whole number from one to three.
Injectable, biodegradable bone cements and methods of making and using same
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.
Injectable, biodegradable bone cements and methods of making and using same
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.

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