University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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Vortex generation for control of the air flow along the surface of an airfoil
Apparatus for generating vortices to control the flow of air across a airfoil of an aircraft includes a series of pressure active regions arranged along the leading edge of the airfoil. The pressure active regions include spaced apart valves connected to a source of vacuum, a controller for activating the valves, and sensors for sensing air pressure. The controller is configured to activate the valves in response to the pressure sensed by the sensors, wherein the spaced apart valves are connected to a source of pressurized air as well as to the source of vacuum.
System for concurrent delivery of thermobrachytherapy in the treatment of cancers
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties.
Novel antagonists of the antidiuretic action of arginine vasopressin
Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is D-Phe, D-Val, D-Leu, D-Ile, D-Arg, D-norvaline, D-norleucine, D-cyclohexylalanine, D-a-aminobutyric acid, D-threonine or D-methionine and Z is D- or L-Arg.
Venting-membrane system to mitigate blast effects
A venting-membrane system for mitigating blast pressure generated from a blast force on a wall structure. The venting-membrane system having a framework including a plurality of parallel structural members defining a wall structure having an interior surface and an exterior surface. At least one inflatable enclosure attached to the interior surface of the wall; and at least one inflatable enclosure attached to the exterior surface of the wall wherein the at least one inflatable enclosure attached to the interior surface of the wall is in communication with the at least one inflatable enclosure attached to the exterior surface of the wall.
4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof
Diazolyl compounds having activity as histamine H3-receptor antagonists, pharmaceutical compositions and methods of using such compounds for treating cognitive disorder or attention or arousal deficit.
Battery charger control system
A battery charger control system and method for maximizing output power to a battery. This is achieved by ensuring operation at either the maximum allowable input current or the thermal limit imposed by the battery charger using an on-line controller. In the invention, the thermal limit is determined by the junction temperatures of the two main IGBT's. Because direct measurement of these temperatures is impractical, they must be calculated by a computer algorithm that uses various on-line measurements. Test results for a 8 kW battery charger indicate reduction in the bulk charging time from conventional battery chargers of about 26% when charging a set of NiFe batteries.
Process to stabilize wastewater sludge
A method for treating wastewater sludge so that a stability based upon achieving a significant microbial population, conductivity level and percent solids, is developed rapidly, is provided for indefinitely and is independent of climatic conditions. A dewatered sludge that has not been treated (i.e., raw) or a sludge that has been treated to a PSRP level or a sludge that has been treated to a PFRP level, i.e., pasteurized or sterilized sludge when still in a wet condition, i.e., between 12%-30% solids, or when in a dry condition, i.e., between 30%-60% solids, is mixed with alkaline adsorptive materials to reduce odor, to increase the percent solids and to facilitate granulation, is adjusted to a mildly alkaline pH, and is adjusted to an ionic conductivity which will allow the sludge to mature rapidly when seeded with a beneficiating microbial flora. This process will reduce the pH of a high alkaline treated sludge, e.g., often above pH 12, to a physiological pH of between 7 and 9.5 or will raise the pH of a treated acid sludge to a similar range so that microbial activity can proceed to facilitate stability. Heat may be applied to the mixture to accelerate the carbonation and aid the overall drying process. The granular product, substantially due to its active microbial population, is useful as an agricultural product and topsoil blend.
HDAC inhibitors as anti-cancer agents
Largazole analogs, methods of making the same, and methods of using the same, are described.
Battery equalization circuit with ramp converter
An electronic battery equalization circuit that equalizes the voltages of a plurality of series connected batteries in a battery pack. The current waveform is in the shape of a ramp for providing zero current switching. The ramp converter power circuit has at least one semiconductor device and a transformer coupled to the equalizing voltage supply source. The transformer has a primary winding circuit and at least one secondary winding circuit. In one embodiment, each secondary winding circuit is connected to a different pair of batteries. The equalizing current is provided to the lowest voltage batteries in one half of the battery pack during one half of the charging cycle. The equalizing current is then provided to the lowest voltage batteries in the other half of the battery pack during the other half of the charging cycle. In another embodiment, each secondary winding circuit is connected to a different single battery. The equalizing current is supplied to a lowest voltage battery in the battery pack during each half of the switching cycle. The electronic battery equalization circuit also includes a feedback control circuit coupled to the primary winding circuit for controlling the current from the equalizing current supply source.
Diels alder adducts of vinyl porphyrins
Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the structures of Formulas 1, 2, 3 and 4, below: ##STR1## where R1, R2, R3 and R4 can be the same or different, and each is methyl, ethyl or an amino acid moiety which is a part of an amide produced by reaction between an amine function of a naturally occurring amino acid and a carbonyl function of the adduct, R5, R6 and R7 can be the same or different, and each is ethyl or an amino acid moiety which is a part of an amide produced by reaction between an amine function of a naturally occurring amino acid and a carbonyl function of the adduct, M comprises a metal cation, e.g., Sn or Zn, that is complexed with two of the nitrogens of the adduct, and R8 is an alkyl group other than t-butyl having from one to four carbon atoms. The use of the adducts and complexes in PHD is also disclosed.
Core muscle strengthening
The method and system of this invention provides for core muscle strengthening. The method comprises the step of: providing an apparatus (10) that provides resistance and assistance during core muscle training using dynamic therapeutic movement for chest, back, abdominal and leg musculature to strengthen and condition muscles of the axial skeleton and lower extremities of a performing user. In one embodiment, the method also is for non-invasive physical therapy.
N-Cyclopentyl-N-2-Hydroxyalkyl-Ring-Substituted Benzamides
Simultaneously acting central nervous system (CNS) depressants and blood pressure depressors of the formula ##SPC1## wherein R is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals; and x is a whole number from one to three.
Intracavitary radiation system
A system is provided for use in brachytherapy where a central tube permits passage of a radioactive source therethrough to deliver a prescribed dosage of radiation. One or more balloons are coaxially positioned around the central tube. At least one balloon includes one or more peripheral tubes extending along at least a portion of the balloon. The peripheral tube is also attached to the high dose rate brachytherapy unit in order to permit passage of a radioactive source therethrough.
N-Cycloalkyl-N'-Cyanoalkyl Alkoxybenzamides
Simultaneously acting central nervous system (CNS) depressants and blood pressure depressors of the formula ##SPC1## Wherein A, B, and C are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals at least one of which is an alkoxy or a halogen radical; wherein x is a whole number from one to three, and wherein R is selected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms.
Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists
The present invention relates to a novel process for the preparation of highly potent histamine receptor antagonists, in particular histamine H3 -receptor antagonists. Also disclosed is a novel process for the preparation of intermediates useful in the preparation of histamine receptor antagonists, in particular H3 -receptor antagonists.
Minimally invasive collapsible cage
An articulating fusible support cage comprises a first support member having a first and second end and a second support member having a first and second end. A first end cap is pivotally connected to the first and second support members at the first ends. The first end cap supports a jackscrew for rotation. A second end cap is pivotally connected to the first and second support members at the second ends opposite the first ends. The second end cap has a threaded sleeve configured to engage a portion of the jackscrew. Rotation of the jackscrew into the threaded sleeve causes the first and second support members to extend outwardly from a collapsed condition to a deployed condition.
Methods for high yield production of furans from biomass sugars at mild operating conditions
Facile methods for high-yield furfural and HMF production from biomass sugars are described. The methods generally involve converting the biomass sugars in high yield to their ketose isomers, resulting in furan production under low temperature and pressure conditions with efficient recycling of the process streams.
Unidirectional rotatory pedicle screw and spinal deformity correction device for correction of spinal deformity in growing children
A scoliosis correction device includes a first fixed anchor that is adapted to be secured to a vertebra of a spine and a second fixed anchor that is adapted to be secured to a vertebra of a spine. A rotatory anchor includes a head portion, a shank portion that extends from the head portion and is adapted to be secured to a vertebra of a spine, and a sprocket that is supported on the head portion for rotational movement relative thereto. A cable extends from the first fixed anchor to the rotatory pedicle screw to the second fixed anchor. The rotatory anchor may be configured to allow unidirectional movement of the sprocket relative to the head portion. A rigid member may extend between the fixed anchor and an intermediate anchor.
Process for transforming gramineae and the products thereof
A method of producing transformed Gramineae comprising making a wound in a seedling in an area of the seedling containing rapidly dividing cells and inoculating the wound with vir+ Agrobacterium tumefaciens. Also, this same method wherein the vir+ A. tumefaciens contains a vector comprising genetically-engineered T-DNA. There are further provided a transformed pollen grain of a Gramineae, a pollen grain of a Gramineae produced by a plant grown from a seedling infected with vir+ A. tumefaciens, a pollen grain of a Gramineae produced by a plant grown from a seedling infected with vir+ A. tumefaciens containing a vector comprising genetically-engineered T-DNA, a pollen grain of a Gramineae whose cells contain a segment of T-DNA, and Gramineae derived from each of these pollen grains. There are also provided a transformed Gramineae plant, a transformed Gramineae plant derived from a seedling infected with vir+ Agrobacterium tumefaciens, a transformed Gramineae plant derived from a seedling infected with vir+ A. tumefaciens containing a vector comprising genetically-engineered T-DNA and a Gramineae plant whose cells contain a segment of T-DNA. Finally, there are provided transformed Gramineae derived from seedlings infected with vir+ Agrobacterium tumefaciens and transformed Gramineae derived from seedlings infected with vir+ A. tumefaciens containing a vector comprising genetically-engineered T-DNA.

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