University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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N-Cycloalkyl-N'-Cyanoalkyl Alkoxybenzamides
Simultaneously acting central nervous system (CNS) depressants and blood pressure depressors of the formula ##SPC1## Wherein A, B, and C are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals at least one of which is an alkoxy or a halogen radical; wherein x is a whole number from one to three, and wherein R is selected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms.
Simulated Fire Apparatus
Simulated fire apparatus wherein a gas or electrically operated flame portrayer is adjusted to vary the type of flame portrayed. Such adjustments are coordinated with adjustments in sound effects produced by a speaker.
N-Substituted-N'-Cycloalkyl-Nitrobenzamides
Simultaneously acting central nervous system (CNS) depressants and blood pressure depressors of the formula ##SPC1## wherein R is selected from the group consisting of alkyl, hydroxyalkoxy, cyanoalkyl, aryl, aralykl, and hydroxyaralkyl radicals and wherein R' is selected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms.
N-Cyclopentyl-N-2-Hydroxyalkyl-Ring-Substituted Benzamides
Simultaneously acting central nervous system (CNS) depressants and blood pressure depressors of the formula ##SPC1## wherein R is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals; and x is a whole number from one to three.
Methods and nitro-benzamide compositions for producing tranquilizing and hypotensive activity
Simultaneously acting tranquilizing and/or hypotensive pharmaceutical compositions comprising effective amounts of compounds of the formula: wherein R is selected from the group consisting of alkyl, hydroxyalkyl, cyanoalkyl, aryl, aralykl, and hydroxyaralkyl radicals; and wherein R' is slected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms.
Methods and cyclopentyl benzamide compositions for producing depressant activity
Simultaneously acting depressants to the central nervous system and the cardiovascular system of the formula ##SPC1## Wherein R is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals; and wherein x is a whole number from 1 to 3.
Methods and benzamide compositions for producing hypotensive activity
Hypotensive pharmaceutical compositions comprising effective amounts of compounds of the formula: ##SPC1## Wherein A, B, and C are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, and halogen radicals at least one of which is an alkoxy or a halogen radical; wherein x is a whole number from one to three, and wherein R is selected from the group consisting of cycloaliphatic radicals containing between three and seven carbon atoms, together with carriers therefor, and the methods for administering said compounds.
Chopper and chopper-multiplexer circuitry for measurement of remote low-level signals
A balanced bridge chopper circuit including four metal oxide semiconductor field effect transistors (MOSFETs) is driven by a remote oscillator connected through an isolator to modulate low-voltage low-frequency input signals at their remote source into a square wave A.C. output signal that can be conducted to a common point where it is amplified and demodulated for better linear measurement of said low-voltage signals. The oscillator is connected through the isolator to the bridge circuit in such a manner that opposing pairs of the bridge transistors are simultaneously conducting. The isolator may comprise a novel photovoltaic isolation device or it may consist of an isolation transformer or of other types of electrical isolation devices. The transistors and input and output terminals for the bridge circuit are shielded and are mounted on a heat sink consisting of a thermally conducting metal plate and/or a metal oxide single crystal which is in common with the shield and/or one terminal of the low-voltage source such that all leads and terminals are maintained at a constant temperature and preferably at the same temperature as the low-voltage source. Air currents are prevented from causing thermally induced voltages within the bridge circuit by the circuit shield and in some extreme cases by the use of a hermetically sealed shield for the critical circuit elements and connections. For accurately balancing out interelectrode capacitance-coupled gate drive to low-level channel signals, a pair of variable capacitors are connected between one output terminal of the bridge circuit and the gate of each of its two adjacent transistors. The balanced bridge chopper may be produced as a monolithic planar-silicon integrated circuit in which gate-to-channel capacitance balancing is accomplished during manufacturing in place of the variable capacitors. A novel balanced input filter and trimmer capacitors between the bridge output terminals and local ground greatly reduce 60 Hz. common mode noise. In a hybrid circuit embodiment of the bridge circuit, the individual MOSFET chips forming the bridge circuit are bonded and interconnected within a hermetically sealed and magnetically transparent metal oxide single crystalline container. Multiplexing circuitry is also disclosed for driving several chopper circuits from a single oscillator and for connecting the outputs from the chopper circuits to a single amplifier and demodulator at a remote location.
Preparation of piperidinyl-alkyl-benzamides
New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula ##STR1## The hydrochlorides which exemplify the salts, have the general formula ##STR2## In the foregoing formulas R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy or trifluoromethyl, n is 1, 2 or 3 when R is methoxy but is otherwise 1, and x is 1, 2 or 3. The hydrochloride salts of the benzamides according to the invention can be produced by the reactions illustrated below: ##STR3## Wherein R, n and x have the meanings set forth above and Y can be --Cl, --F, or --OCH3.
Chopper-multiplexer system for measurement of remote low-level signals
A balanced bridge chopper circuit including four metal oxide semiconductor field effect transistors (MOSFETs) is driven by a remote oscillator connected through an isolator to modulate low-voltage low-frequency input signals at their remote source into a square wave A.C. output signal that can be conducted to a common point where it is amplified and demodulated for better linear measurement of said low-voltage signals. The oscillator is connected through the isolator to the bridge circuit in such a manner that opposing pairs of the bridge transistors are simultaneously conducting. The isolator may comprise a novel photovoltaic isolation device or it may consist of an isolation transformer or of other types of electrical isolation devices. The transistors and input and output terminals for the bridge circuit are shielded and are mounted on a heat sink consisting of a thermally conducting metal plate and/or a metal oxide single crystal which is in common with the shield and/or one terminal of the low-voltage source such that all leads and terminals are maintained at a constant temperature and preferably at the same temperature as the low-voltage source. Air currents are prevented from causing thermally induced voltages within the bridge circuit by the circuit shield and in some extreme cases by the use of a hermetically sealed shield for the critical circuit elements and connections. For accurately balancing out interelectrode capacitance-coupled gate drive to low-level channel signals, a pair of variable capacitors are connected between one output terminal of the bridge circuit and the gate of each of its two adjacent transistors. The balanced bridge chopper may be produced as a monolithic planar-silicon integrated circuit in which gate-to-channel capacitance balancing is accomplished during manufacturing in place of the variable capacitors. A novel balanced input filter and trimmer capacitors between the bridge output terminals and local ground greatly reduce 60 Hz. common mode noise. In a hybrid circuit embodiment of the bridge circuit, the individual MOSFET chips forming the bridge circuit are bonded and interconnected within a hermetically sealed and magnetically transparent metal oxide single crystalline container. Multiplexing circuitry is also disclosed for driving several chopper circuits from a single oscillator and for connecting the outputs from the chopper circuits to a single amplifier and demodulator at a remote location.
Lime-fly ash-aggregate-sludge paving material
A composition and method for producing an improved lime-fly ash-aggregate is disclosed. The composition is prepared by mixing together lime, flyash, graded aggregate, adding water, and from 0.5 to 4 percent, based on total dry weight, of sludge from a water treatment plant. The mixture is placed on top of a prepared subgrade, spread uniformly, and compacted to a high degree of relative density to provide the main load-carrying component of a road, airport runway, parking lot or the like.
Method for determining stress-optical constants of optically isotropic and anisotropic materials
A method for optically determining the stress-optical constants of optically isotropic and anisotropic materials. A collimated beam of monochromatic light is directed at the tip of a crack in a thin plate specimen under plane-stress from a direction substantially perpendicular to the surface of the specimen and to the direction of the stress. Reflected and transmitted stress-optical constants are determined from a ratio of the diameters of transmitted and reflected caustics from the specimen and the known Poisson's ratio and modulus of elasticity for the specimen.
Method for increasing the hydrogen:carbon ratio of an organic compound
A method for increasing the hydrogen:carbon ratio of an organic compound is disclosed. The organic compound can be one having any of the following functions: hydroxyl, carbonyl, epoxide, acetal, ketal, hemiacetal and hemiketal. The method involves introducing the organic compound and a silicon hydride into a liquid which is either chemically inert or acidic and introducing BF3 into the liquid to produce a reaction product having a higher hydrogen:carbon ratio than the starting organic compound. Examples of organic compound starting materials disclosed include undecanal, benzaldehyde, p-methylbenzaldehyde, p-chlorobenzaldehyde, p-methoxybenzaldehyde, p-cyanobenzaldehyde, p-nitrobenzaldehyde, 2-undecanone, cyclohexanone, 2-methylcyclohexanone, adamantanone, p-cyanoacetophenone, fluorenone, 1-naphthaldehyde, p-nitroacetophenone, fructose and cotton. The use, as the silicon hydride, of triethylsilane, (R)-(+)-1-naphthylphenylmethylsilane, dimethylethylsilane, phenylneopentylmethylsilane, and of tri-n-hexylsilane is disclosed, while methylene chloride is disclosed as the liquid in which the reaction is conducted.
Method for determining properties of optically isotropic and anisotropic materials
A method for optically determining the ratio of Poisson's ratio to modulus of elasticity for optically isotropic and optically anisotropic transparent materials and then for determining the stress-optical constants for such materials. A collimated monochromatic light beam is directed at the tip of a crack in a loaded thin plate specimen of the material and the diameters of the resulting transmitted and reflected caustics are measured at points equidistant from the specimen. The light beam also is directed to an uncracked region in a loaded thin plate specimen of the material and the number of displaced fringe reflected on a screen are counted for a predetermined change in loading. The ratio of Poisson's ratio to modulus of elasticity and the stress-optical constants are determined from the thickness of the specimen, the displaced fringe count, the wavelength of the light beam and the ratio of the caustic diameters.
Tissue culture system
A tissue culture system for zero gravity high-density cultivation of eucaryotic cells requiring attachment to a substratum in order to differentiate is disclosed. A major component of the system is a cylindrical bottle filled with culture medium and having mounted therein a rotatable shaft. The shaft includes a plurality of collagen-treated discs projecting therefrom and at an angle to the shaft to provide the necessary attachment substratum and to impel the culture medium as the shaft is rotated. Means are provided for initial stocking of the bottle with the culture cells and for continuously supplying fresh medium to and removing waste medium from the bottle.
Methods and piperidinyl-alkyl-benzamide composition for inhibiting H2 histamine receptors
Pharmaceutical compositions for the treatment of ulcerative disorders comprising therapeutically effective amounts of compounds of the formula: ##STR1## wherein R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy, or where R is meta trifluoromethyl, n is 1, 2, or 3 when R is methoxy, but is otherwise 1, and x is 1, 2, or 3, with the proviso that when n is 1, R in the meta position is trifluoromethyl or hydrogen, and physiologically acceptable salts thereof.
A.C. Motor control circuit
A microprocessor based A.C. motor control circuit which can be used for both open and closed loop control includes a pair of RAMs for storing separate groups of synchronized digital waveforms for driving an A.C. motor. The microprocessor is used to calculate the group of digital waveforms required to maintain a controlled motor parameter at a desired value. One RAM has an output connected to supply the group of digital waveforms stored therein to a motor driver, while the second RAM is connected to receive a new group of digital waveforms which have just been calculated by the microprocessor. Once the new group of waveforms have been loaded into the second RAM, the microprocessor generates control signals to disconnect the output of the first RAM from the motor driver, and to connect the output of the second RAM to supply the newly calculated digital waveforms to the motor driver. The first RAM is then connected to receive the next group of digital waveforms to be calculated by the microprocessor.
Tissue culture device for mass cell culture
A multiplate, cell propagation device for use in tissue culture having an elongate enclosed vessel containing a plurality of parallel, spaced apart discs secured for rotation within the vessel. The device includes a cradle-like frame for holding the discs in place during rotation thereof, with the entire frame or individual discs being removable from the vessel without disturbing other discs. Means are provided on the frame for selectively holding the discs in place.
Instrument for measuring the range of motion associated with a human body joint
The present invention relates to an instrument for measuring the range of angular displacement associated with two human body portions connected to a common joint. The instrument includes two pivotally connected, elongate rods, and separate supports for supporting each of the rods on a respective one of the body portions in spaced relationship with the body portion. Each of the supports includes a pair of ball and socket assemblies which are mounted on the respective body portions in spaced relation to one another. The ball of each ball and socket assembly has an aperture formed therethrough for receiving the associated elongate rod. Such a support arrangement enables the body portions to be rotated about the common joint without affecting the natural movements of the body portions. An encoder is utilized to pivotally connect the two elongate rods and to generate an electrical output signal representing the relative angular position between the two rods. A counter and display circuit is responsive to the encoder output signal for determining the change in angular position between the two rods and displaying this value in terms of angular degrees.
Expandable intramedullary nail for the fixation of bone fractures
The present invention relates to an improved expandable intramedullary nail for the fixation of bone fractures. The nail includes an elongate sleeve having one end adapted to be inserted within the medullary cavity of the bone. The one end of the sleeve is formed of a predetermined maximum retracted diameter to permit the insertion of the one end within the bone cavity. A plurality of circumferentially spaced, radially expandable elements are carried by the one end of the sleeve. The elements are radially movable from a first, retracted position wherein the elements define a first diameter to a second, expanded position wherein the elements define a second diameter greater than the predetermined maximum retracted diameter and the first diameter. In accordance with the present invention, when the elements are in the expanded position, the elements provide at least two support points at the second diameter and axially spaced along the sleeve for engagement with the inner wall of the bone cavity. A camming member is carried by the one end of the elongate sleeve for moving the elements from the retracted position to the expanded position. An actuator is located at the other end of the sleeve and is coupled to operate the camming member for controlling the radial position of the elements.

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