University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
Method for modifying surfaces for better osseointegration
In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate.
Methods for high yield production of furans from biomass sugars at mild operating conditions
Facile methods for high-yield furfural and HMF production from biomass sugars are described. The methods generally involve converting the biomass sugars in high yield to their ketose isomers, resulting in furan production under low temperature and pressure conditions with efficient recycling of the process streams.
Bone graft material mixing and delivery device
Described herein are bone graft material (BGM) delivery devices having a tray configured to provide a mixing and/or holding area for BGM to substantially prevent BGM from inadvertently being delivered to an unacceptable surgical site.
Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same
Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
Iron pyrite nanocrystal film as a copper-free back contact for polycrystalline CdTe thin film solar cells
The invention discloses nanocrystalline (NC) FeS2 thin films as the back contact for CdTe solar cells. In one example, the FeS2 NC layer is prepared from a solution directly on the CdTe surface using spin-casting and chemical treatment at ambient temperature and pressure, without a thermal treatment step. Solar cells prepared by applying the NC FeS2 back contact onto CdTe yield efficiencies of about 95% to 100% that of standard Cu/Au back contact devices. In another example, FeS2 is interposed between Cu and Au to form a Cu/FeS2 NC/Au back contact configuration yielding an efficiency improvement of 5 to 9 percent higher than standard Cu/Au devices.
Injectable, biodegradable bone cements and methods of making and using same
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium, magnesium, or strontium, a setting solution comprising H3PO4 and a buffer, and a biocompatible polymer that is incorporated into the setting solution. The powder is mixed with the setting solution to form a bone cement paste that either (a) sets into a hardened mass, or (b) is irradiated with electromagnetic radiation to form dry powders, the dry powders then being mixed with a second setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.
Magnetic ionic liquids, methods of making and uses thereof as solvents in the extraction and preservation of nucleic acids
Described herein are methods for making and using magnetic ionic liquid that have at least one cationic component and at least one anionic component, where at least one of the cationic components or the anionic components is a paramagnetic component. The magnetic ionic liquids are capable of manipulation by an external magnetic field.
Xenoantigen-displaying anti-cancer vaccines and method of making
Compositions, methods of making, and methods of using, xenoantigen-displaying anti-cancer vaccines are described.
Use of acyl-homoserine lactone derivatives as anti-thrombotic agents
Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit platelets from becoming hypersensitive, and/or to prevent thrombosis, are described.
Hybrid multifunctional posterior interspinous fusion device
This invention relates to an improved structure for an interspinous stabilization device that more evenly distributes loads throughout the adjacent vertebrae than known interspinous stabilization devices, and further readily compensates for graft settling so as to maintain continued axial loading of the graft. More specifically, this invention relates to a medical device that helps in performing a spinal fusion procedure by holding the bone graft in place and stabilizing the facet screw by a plate that is attached to it. The invention also performs a dynamic function that compensates for settling of the bone graft over time. This dynamic function may, if desired, be enhanced by a movement-limiting mechanism that allows extension but not flexion such that the bone graft fusion remains in contact and fusion takes place.
High-yield production of fuels and petro- and oleo-chemical precursors from vegetable oils and other liquid feedstocks in a cont
Systems, methods, and materials for pyrolyzing vegetable oil feedstocks to obtain high yields of various products are described.
Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
Methods and devices for detection and measurement of analytes
Sensors for target entities having functionalized thereon, at least one aptamer specific to the target entity, and methods of making and using the same are described for use in glycated protein monitoring and/or biomarkers.
Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
Amorphous polyester from bio-based bis-furan assembly
Polymers, including polyesters and polycarbonates comprising residue of bis-furan diol, which is produced from renewable furfural feedstock, and methods of making and using those polyesters and polycarbonates are described. The method includes reacting a bis-furan diol with a dicarboxylic acid in the presence of a carbodiimide to produce the bis-furan containing polymers. In certain embodiments, the dicarboxylic acid is succinic acid, the bis-furan diol is the 5,5'-(propane-2,2-diyl)bis(furan-2,5-diyl) dimethanol, and the carbodiimide is of N,N-diisopropylcarbodiimide.
Microalgae harvesting using stimuli-sensitive hydrogels
A harvesting device and methods of harvesting (i.e., dewatering) algae are described. The harvesting device and methods involve the use of stimuli-sensitive hydrogels.
Method for modulating pigmentation by targeting BET bromodomain proteins
Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein inhibitors, such as JQ1, are used to reduce pigmentation, promote cell cycle arrest, inhibit the expression of TYR, TRP1, and DCT proteins, inhibit the expression of TYR mRNA, and suppress melanocyte proliferation.
Injectable, biodegradable bone cements and methods of making and using same
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.

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