University of Toledo U.S. Patents

This collection includes United States patents for inventions by UT faculty, students and staff that list UT/MCO/MUO as the original assignee (owner). These patents include those assigned to the University of Toledo as well as to the Medical College of Ohio/Medical University of Ohio prior to the merger in 2006. Only granted patents, not patent applications, are included. Use the 'Search within this Series' box to search for keywords in the authors, titles, or abstracts of the patents.

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(4-L-Threonine)-Mesotocin
A novel biologically active (4-L-threonine)-mesotocin which is an analog of mesotocin in which the glutamine residue in position four is replaced by a threonine residue.
(4-L-Threonine)-Oxytocin
A novel biologically active (4-L-threonine)-oxytocin which is an analog of oxytocin in which the glutamine residue in position four is replaced by a threonine residue.
4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof
Diazolyl compounds having activity as histamine H3-receptor antagonists, pharmaceutical compositions and methods of using such compounds for treating cognitive disorder or attention or arousal deficit.
A.C. Motor control circuit
A microprocessor based A.C. motor control circuit which can be used for both open and closed loop control includes a pair of RAMs for storing separate groups of synchronized digital waveforms for driving an A.C. motor. The microprocessor is used to calculate the group of digital waveforms required to maintain a controlled motor parameter at a desired value. One RAM has an output connected to supply the group of digital waveforms stored therein to a motor driver, while the second RAM is connected to receive a new group of digital waveforms which have just been calculated by the microprocessor. Once the new group of waveforms have been loaded into the second RAM, the microprocessor generates control signals to disconnect the output of the first RAM from the motor driver, and to connect the output of the second RAM to supply the newly calculated digital waveforms to the motor driver. The first RAM is then connected to receive the next group of digital waveforms to be calculated by the microprocessor.
AC to DC converter system with ripple feedback circuit
A nonlinear ripple feedback circuit for use with a current-sourced rectifier system with an inductor input filter. The nonlinear ripple feedback circuit eliminates the oscillation of the rectifiers and improves the line-current waveform by sensing of and compensating for any amplitude of ripple appearing in the DC-side current. A sample of the rectified line voltage is multiplied by the product of a voltage feedback control signal times the ripple feedback signal ratio to form the input to the pulse-width modulator which produces the gating waveform for the converter of the rectifier system such that the oscillation and sensitivity of the converter system is reduced, and the AC line current waveform has low distortion, regardless of the DC-side ripple current levels.
AC to DC converter system with ripple feedback circuit
A ripple feedback circuit for use with a current-sourced rectifier system with a resonant load balancing filter. The ripple feedback circuit eliminates the oscillation of the rectifiers and improves the line-current waveform by sensing the low frequency AC components of the output current and by combining such AC components with the control voltage at the input to the multiplier of the pulse width modulator of the rectifier system. A sample of the rectified line voltage is multiplied by the control voltage less ripple feedback to form the input to the pulse-width modulator which produces the gating waveform for the converter of the rectifier system.
Active suspension systems and components using piezoelectric sensing and actuation devices
A lightweight, high performance, active suspension system utilizing piezoelectric regulated springs, and a method of manufacturing the suspension system, is described. Piezoelectric material is bonded to suspension springs, and excited appropriately to vary the stiffness of the suspension system. A method of controlling the stiffness of a spring includes piezoelectric material bonded to the spring, a sensor system for generating a signal proportional to the loading imposed on the spring, and controller for exciting the piezoelectric material in response to the signal. A control system for controlling the stiffness of a spring including embedding a plurality of piezoelectric particles within an electrically conductive matrix forming the body of the spring is also described.
Agrobacterium mediated transformation of germinating plant seeds
A non-tissue culture process using Agrobacterium-mediated vectors to produce transgenic plants from seeds of such plants as the common bean and soybean.
Agrobacterium mediated transformation of germinating plant seeds
A non-tissue culture process using Agrobacterium-mediated vectors to produce transgenic plants from seeds of such plants as the common bean and soybean.
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed. The composition also is modified with an indicator reagent such as chromophores.
Aldose-ketose transformation for separation and/or chemical conversion of C6 and C5 sugars from biomass materials
Systems for converting aldose sugars to ketose sugars and separating and/or concentrating these sugars using differences in the sugars' abilities to bind to specific affinity ligands are described.
Altered peptide ligands of GAD65
Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes.
Amine-terminated aptamer functionalized surface plasmon resonanace sensors, methods of making and methods of using same
Sensors for target entities having functionalized thereon, at least one amine-terminated aptamer specific to the target entity, and methods of making and using the same are described.
Amorphous polyester from bio-based bis-furan assembly
Polymers, including polyesters and polycarbonates comprising residue of bis-furan diol, which is produced from renewable furfural feedstock, and methods of making and using those polyesters and polycarbonates are described. The method includes reacting a bis-furan diol with a dicarboxylic acid in the presence of a carbodiimide to produce the bis-furan containing polymers. In certain embodiments, the dicarboxylic acid is succinic acid, the bis-furan diol is the 5,5'-(propane-2,2-diyl)bis(furan-2,5-diyl) dimethanol, and the carbodiimide is of N,N-diisopropylcarbodiimide.
Amorphous polyester from bio-based bis-furan assembly
Polymers, including Polyesters and Polycarbonates comprising residue of bis-furan diol, which is produced from renewable furfural feedstock and methods of making and using of those polyesters and polycarbonates are described. The method includes reacting a bis-furan diol with a dicarboxylic acid in the presence of a carbodiimide to produce the bis-furan containing polymers. In certain embodiments, the dicarboxylic acid is succinic acid; the bis-furan diol is the 5,5'-(propane-2,2-diyl)bis(furan-2,5-diyl) dimethanol and the carbodiimide is of N,N-diisopropylcarbodiimide.
Analogs of peroxisome proliferator activated receptor (PPAR) agonists, and methods of using the same
Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed.

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