Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same

Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).
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Abstract/Description: Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).
Subject(s):
C07F9/6544
A61P9/10
A61P19/02
A61P25/16
A61P25/22
A61P25/24
A61P25/28
A61P29/00
C07D279/12
Date Issued: 2021-08-10