Methods of treatment of cancer using SRC-modulating peptides

A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. Also disclosed is use of said Src-modulating peptides for treatment of cancer.
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Abstract/Description: A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. Also disclosed is use of said Src-modulating peptides for treatment of cancer.
Subject(s): A61K38/10
C07K14/47
A61K38/45
A61K38/46
C07K7/08
G01N33/573
A61K38/17
Date Issued: 2017-05-30
Title: Methods of treatment of cancer using SRC-modulating peptides.
Name(s): The University of Toledo, assignee
Xie, Zi-jian, inventor
Shapiro, Joseph I., inventor
Tian, Jiang, inventor
Li, Zhichuan, inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 2015-01-28
Date Issued: 2017-05-30
Physical Form: application/pdf
Extent: 78 p.
Abstract/Description: A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. Also disclosed is use of said Src-modulating peptides for treatment of cancer.
Identifier(s): utpatents-US9663561 (IID)
Patent No.: US9663561 (patno)
Appl. No.: 14/607426 (appno)
Subject(s): A61K38/10
C07K14/47
A61K38/45
A61K38/46
C07K7/08
G01N33/573
A61K38/17
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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